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Tertiary Element Interaction in HIV-1 TAR.

Tertiary Element Interaction in HIV-1 TAR.
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Krawczyk K, Sim AY, Knapp B, Deane CM, Minary P,


Krawczyk K, Sim AY, Knapp B, Deane CM, Minary P, (click to view)

Krawczyk K, Sim AY, Knapp B, Deane CM, Minary P,

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Journal of chemical information and modeling 2016 8 17()

Abstract

HIV-1 replication requires binding to occur between Trans-activation Response Element (TAR) RNA and the TAT protein. This TAR-TAT binding depends on the conformation of TAR, and therapeutic development has attempted to exploit this dynamic behavior. Here we simulate TAR dynamics in the context of mutations inhibiting TAR binding. We find that two tertiary elements, the apical loop and the bulge, can interact directly, and this interaction may be linked to the affinity of TAR for TAT.

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