Advertisement

 

 

Tissue adaptation of regulatory and intraepithelial CD4+ T cells controls gut inflammation.

Author Information (click to view)

Sujino T, London M, Hoytema van Konijnenburg DP, Rendon T, Buch T, Silva HM, Lafaille JJ, Reis BS, Mucida D,


Sujino T, London M, Hoytema van Konijnenburg DP, Rendon T, Buch T, Silva HM, Lafaille JJ, Reis BS, Mucida D, (click to view)

Sujino T, London M, Hoytema van Konijnenburg DP, Rendon T, Buch T, Silva HM, Lafaille JJ, Reis BS, Mucida D,

Advertisement
Share on FacebookTweet about this on TwitterShare on LinkedIn

Science (New York, N.Y.) 2016 6 2() pii

Abstract

Foxp3(+) regulatory T cells in peripheral tissues (pTregs) are instrumental in limiting inflammatory responses to non-self antigens. Within the intestine, pTregs are located primarily in the lamina propria, while intraepithelial CD4(+) T cells (CD4IELs), which also exhibit anti-inflammatory properties and depend on similar environmental cues, reside in the epithelium. Using intravital microscopy, we show distinct cell dynamics of intestinal Tregs and CD4IELs Upon migration to the epithelium, Tregs lose Foxp3 and convert to CD4IELs in a microbiota-dependent fashion, an effect attributed to the loss of the transcription factor ThPOK. Finally, we demonstrate that pTregs and CD4IELs perform complementary roles in the regulation of intestinal inflammation. These results reveal intra-tissue specialization of anti-inflammatory T cells shaped by discrete niches of the intestine.

Submit a Comment

Your email address will not be published. Required fields are marked *

nineteen − 10 =

[ HIDE/SHOW ]