Advertisement

 

 

Treatment Outcomes for Patients with Extensively Drug-Resistant Tuberculosis, KwaZulu-Natal and Eastern Cape Provinces, South Africa.

Treatment Outcomes for Patients with Extensively Drug-Resistant Tuberculosis, KwaZulu-Natal and Eastern Cape Provinces, South Africa.
Author Information (click to view)

Kvasnovsky CL, Cegielski JP, van der Walt ML,


Kvasnovsky CL, Cegielski JP, van der Walt ML, (click to view)

Kvasnovsky CL, Cegielski JP, van der Walt ML,

Advertisement
Share on FacebookTweet about this on TwitterShare on LinkedIn

Emerging infectious diseases 22(9) doi 10.3201/eid2209.160084

Abstract

We analyzed data for a retrospective cohort of patients treated for extensively drug-resistant tuberculosis in 2 provinces in South Africa and compared predictors of treatment outcome in HIV-positive patients who received or had not received antiretroviral drugs with those for HIV-negative patients. Overall, 220 (62.0%) of 355 patients were HIV positive. After 2 years, 34 (10.3%) of 330 patients with a known HIV status and known outcome had a favorable outcome. Multivariate analysis showed that predictors of favorable outcome were negative results for acid-fast bacilli by sputum microscopy at start of treatment and weight >50 kg. HIV-positive patients were more likely to have an unfavorable outcome. The strongest predictor of unfavorable outcome was weight <50 kg. Overall outcomes were poor. HIV status was not a predictor of favorable outcome, but HIV-positive patients were more likely to have an unfavorable outcome. These results underscore the need for timely and adequate treatment for tuberculosis and HIV infection.

Submit a Comment

Your email address will not be published. Required fields are marked *

5 + five =

[ HIDE/SHOW ]