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Xenogeneic Silencing and Its Impact on Bacterial Genomes.

Xenogeneic Silencing and Its Impact on Bacterial Genomes.
Author Information (click to view)

Singh K, Milstein JN, Navarre WW,


Singh K, Milstein JN, Navarre WW, (click to view)

Singh K, Milstein JN, Navarre WW,

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Annual review of microbiology 2016 06 1770() 199-213 doi 10.1146/annurev-micro-102215-095301

Abstract

The H-NS (heat-stable nucleoid structuring) protein affects both nucleoid compaction and global gene regulation. H-NS appears to act primarily as a silencer of AT-rich genetic material acquired by horizontal gene transfer. As such, it is key in the regulation of most genes involved in virulence and in adaptation to new environmental niches. Here we review recent progress in understanding the biochemistry of H-NS and how xenogeneic silencing affects bacterial evolution. We highlight the strengths and weaknesses of some of the models proposed in H-NS-mediated nucleoprotein complex formation. Based on recent single-molecule studies, we also propose a novel mode of DNA compaction by H-NS termed intrabridging to explain over two decades of observations of the H-NS molecule.

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