Advertisement

 

 

18ß-glycyrrhetinic acid derivative promotes proliferation, migration and aquaporin-3 expression in human dermal fibroblasts.

18ß-glycyrrhetinic acid derivative promotes proliferation, migration and aquaporin-3 expression in human dermal fibroblasts.
Author Information (click to view)

Hung CF, Hsiao CY, Hsieh WH, Li HJ, Tsai YJ, Lin CN, Chang HH, Wu NL,


Hung CF, Hsiao CY, Hsieh WH, Li HJ, Tsai YJ, Lin CN, Chang HH, Wu NL, (click to view)

Hung CF, Hsiao CY, Hsieh WH, Li HJ, Tsai YJ, Lin CN, Chang HH, Wu NL,

Advertisement
Share on FacebookTweet about this on TwitterShare on LinkedIn

PloS one 2017 08 1612(8) e0182981 doi 10.1371/journal.pone.0182981
Abstract

Licorice (Glycyrrhiza) species have been widely used as a traditional medicine and a natural sweetener in foods. The 18β-glycyrrhetinic acid (18β-GA) is a bioactive compound in licorice that exhibits potential anti-cancer, anti-inflammatory, and anti-microbial activities. Many synthesized derivatives of 18β-GA have been reported to be cytotoxic and suggested for the treatment of malignant diseases. In this study, we explored the possible pharmacological roles of an 18β-GA derivative in skin biology using primary human dermal fibroblasts and HaCaT keratinocytes as cell models. We found that this 18β-GA derivative did not cause cell death, but significantly enhanced the proliferation of dermal fibroblasts and HaCaT keratinocytes. A scratch wound healing assay revealed that the 18β-GA derivative promoted the migration of fibroblasts. Due to the important role of aquaporin-3 in cell migration and proliferation, we also investigated the expression of aquaporin-3 and found this compound up-regulated the expression of aquaporin-3 in dermal fibroblasts and HaCaT keratinocytes. In dermal fibroblasts, the 18β-GA derivative induced the phosphorylation of Akt, ERK, and p38. The inhibitor of Akt predominantly suppressed the 18β-GA derivative-induced expression of aquaporin-3. Collectively, this compound had a positive effect on the proliferation, migration, and aquaporin-3 expression of skin cells, implying its potential role in the treatment of skin diseases characterized by impaired wound healing or dermal defects.

Submit a Comment

Your email address will not be published. Required fields are marked *

19 − one =

[ HIDE/SHOW ]