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25-hydroxy Vitamin D Suppresses Hepatitis C Virus Replication and Contributes to Rapid Virological Response of Treatment Efficacy.

25-hydroxy Vitamin D Suppresses Hepatitis C Virus Replication and Contributes to Rapid Virological Response of Treatment Efficacy.
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Huang JF, Ko YM, Huang CF, Yeh ML, Dai CY, Hsieh MH, Huang CI, Yang HL, Wang SC, Lin ZY, Chen SC, Yu ML, Chuang WL,


Huang JF, Ko YM, Huang CF, Yeh ML, Dai CY, Hsieh MH, Huang CI, Yang HL, Wang SC, Lin ZY, Chen SC, Yu ML, Chuang WL, (click to view)

Huang JF, Ko YM, Huang CF, Yeh ML, Dai CY, Hsieh MH, Huang CI, Yang HL, Wang SC, Lin ZY, Chen SC, Yu ML, Chuang WL,

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Hepatology research : the official journal of the Japan Society of Hepatology 2017 02 22() doi 10.1111/hepr.12878

Abstract
AIM
25-hydroxy vitamin D (Vit D) plays a role in treatment outcomes in chronic hepatitis C virus (HCV) infection (CHC). We aimed to clarify HCV replication is inhibited by Vit D in HCV replicon cells. Clinical implication was assessed for rapid virological response (RVR) and sustained virological response (SVR) among those patients receiving anti-viral therapy.

METHODS
Cell survival and viral loads were observed in Con1 (genotype-1b) and J6/JFH (genotype-2a) cells treated with different doses of Vit D. Three groups of patients with different treatment responses were recruited to assess their Vit D levels: Group A (RVR-/SVR-); Group B (RVR+/SVR-); Group C (RVR+/SVR+).

RESULTS
The viral load of Con1 cells decreased by 69%, 80%, and 86%, in 1 μM, 5 μM, and 10 μM Vit D, respectively (p < 0.0001). In J6/JFH cells, it decreased by 12%, 55%, and 80.5% in 1 μM, 5 μM, and 10 μM Vit D, respectively (p < 0.0001). There was a significant increase of Vit D between CHC groups, ranging from 4.4 ± 5.6 ng/mL of group A (n = 44), 17.2 ± 11.6 ng/mL of group B (n = 44), to 32.5 ± 37.5 ng/mL of group C (n = 44) (P < 0.001). Advanced fibrosis (odds ratio = 0.13, 95% confidence interval = 0.04-0.41, P < 0.001) and Vit D deficiency (<10 ng/mL) (odds ratio = 0.11, 95% confidence interval = 0.03-0.43, P = 0.001) were predictive of SVR in the multivariate regression analysis. CONCLUSION
Vit D decreases HCV replication and also contributes to early treatment viral kinetics.

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