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8th edition of AJCC/TNM staging system of thyroid cancer: what to expect.

8th edition of AJCC/TNM staging system of thyroid cancer: what to expect.
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Lamartina L, Grani G, Arvat E, Nervo A, Zatelli MC, Rossi R, Puxeddu E, Morelli S, Torlontano M, Massa M, Bellantone R, Pontecorvi A, Montesano T, Pagano L, Daniele L, Fugazzola L, Ceresini G, Bruno R, Rossetto R, Tumino S, Centanni M, Meringolo D, Castagna MG, Salvatore D, Nicolucci A, Lucisano G, Filetti S, Durante C,


Lamartina L, Grani G, Arvat E, Nervo A, Zatelli MC, Rossi R, Puxeddu E, Morelli S, Torlontano M, Massa M, Bellantone R, Pontecorvi A, Montesano T, Pagano L, Daniele L, Fugazzola L, Ceresini G, Bruno R, Rossetto R, Tumino S, Centanni M, Meringolo D, Castagna MG, Salvatore D, Nicolucci A, Lucisano G, Filetti S, Durante C, (click to view)

Lamartina L, Grani G, Arvat E, Nervo A, Zatelli MC, Rossi R, Puxeddu E, Morelli S, Torlontano M, Massa M, Bellantone R, Pontecorvi A, Montesano T, Pagano L, Daniele L, Fugazzola L, Ceresini G, Bruno R, Rossetto R, Tumino S, Centanni M, Meringolo D, Castagna MG, Salvatore D, Nicolucci A, Lucisano G, Filetti S, Durante C,

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Endocrine-related cancer 2017 11 30() pii 10.1530/ERC-17-0453

Abstract

The 8th edition of AJCC/TNM staging system for differentiated thyroid cancer (DTC) has recently been published. The aim of this study was to compare AJCC/TNM staging 7th and 8th edition in terms of tumor stage distribution in a multicenter, consecutive and prospective cohort of newly diagnosed DTC collected in a web-based observational database. Additional information concerning the extent of minimal extrathyroidal extension was collected. A cohort of 1765 DTC patients (76% females, median age 48 years, 94% papillary histotype) was analyzed. Younger patients (<45 years or <55 years according to 7th and 8th edition, respectively) were in stage II (presence of distant metastases) in 2% of the cases with both classifications. According to TNM 7th edition in patients aged ≥45 years (N=1067), stage distribution was: stage I 595 (56%), stage II 85 (8%), stage III 283 (26%), and stage IV 104 (10%). According to TNM 8th edition in patients aged ≥55 years (N=615) was: stage I 391 (64%), II 193 (31%), III 15 (2%) and IV 16 (3%). The 27% of the patients were downstaged with TNM 8th edition. The majority of newly diagnosed DTC patients are in low-risk stages. An important downstaging is observed applying TNM 8th edition.

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