Biomarker-Based Strategies for Immunotherapy in Localized Colorectal Cancer
The following is a summary of “Introducing Neoadjuvant Immunotherapy for Colorectal Cancer:...
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Showing 1 - 20 of 2101 results for 'Colorectal cancer'
Reduced Follow-Up Frequency Safe After Colorectal Cancer Surgery
More frequent follow-up after curative surgery did not significantly reduce 10-year mortality rates in patients with stage II and stage III colorectal cancer.
Read MoreReplication Study and Meta-Analysis of the Contribution of Seven Genetic Polymorphisms in Immune-Related Genes to the Risk of Gastric and Colorectal Cancers.
Recently, it has been realized that immune processes participate in the pathogenesis of human cancers. A large number of genetic polymorphisms in immune-related genes have been extensively examined for their roles in the...
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Rise in Early-Onset Colorectal Cancer Mortality From 2000 to 2022
Early-onset colorectal cancer mortality rose in the United States in the past 2 decades, according to findings from the American College of Gastroenterology.
Read MoreA Systematic Review and Meta-Analysis of the Efficacy and Safety of Regorafenib in the Treatment of Metastatic Colorectal Cancer.
Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide. Despite advances in treatment, metastatic colorectal cancer (mCRC) remains a significant challenge due to its heterogeneity and resistance to...
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#VisualAbstract: Nivolumab Plus Ipilimumab Increased Pro-gression-Free Survival in Microsatellite-In-stability-High Metastatic Colorectal Cancer
Click here to read this study in NEJM. ©2024 2 Minute Medicine, Inc. All rights reserved. No...
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Serum Ferritin and Other Iron Markers in Colorectal Cancer Risk Analysis
The following is a summary of “Association between serum iron status and the risk of colorectal...
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Colorectal Cancer Risk Factors Important to Consider for Rescreening Interval
TUESDAY, Dec. 3, 2024 (HealthDay News) — Colorectal cancer (CRC) risk factors are important...
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Nivolumab plus Ipilimumab in MSI-High Metastatic Colorectal Cancer
1. Progression-free survival at 12 months was 79% with nivolumab/ipilimumab vs 21% with...
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Investigating the biomarker value of circRNAs in the diagnosis of colorectal cancer: a systematic review.
Circular RNAs (circRNAs) has recently been considered a class of endogenous RNAs that form a continuous closed loop with an ability to cancer development. Due to its properties, circRNAs has promising potential to be considered...
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Fluorouracil, leucovorin and irinotecan plus panitumumab for the treatment of metastatic colorectal cancer
1. An intermittent strategy with fluorouracil, leucovorin and irinotecan (FOLFIRI) plus...
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Racial, Ethnic Disparities Seen in Mortality With Early-Onset Colorectal Cancer
TUESDAY, Nov. 26, 2024 (HealthDay News) — Racial and ethnic disparities exist in early-onset...
Read More4-(Pyrazolyl)benzenesulfonamide Ureas as Carbonic Anhydrases Inhibitors and Hypoxia-Mediated Chemo-Sensitizing Agents in Colorectal Cancer Cells.
Hypoxia in tumors contributes to chemotherapy resistance, worsened by acidosis driven by carbonic anhydrases (CA IX and XII). Targeting these enzymes can mitigate acidosis, thus enhancing tumor sensitivity to cytotoxic drugs....
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USPSTF Recommendation Boosted Colorectal Cancer Screening
Following the 2021 USPSTF recommendation on colorectal cancer screening, uptake of such screenings increased from 0.50% to 1.51%.
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Fecal immunochemical testing may be efficient for colorectal cancer screening in younger patients
1. In this retrospective cohort study, fecal immunochemical test completion rates in individuals...
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Novel colorectal cancer screening tests’ utility depends on patient context
1. Based on a validated model of colorectal cancer screening, cell-free DNA blood tests may...
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Link Between T2D, Sulfonylurea Use, and Colorectal Cancer Risk
The following is a summary of “Effect of diabetes mellitus type 2 and sulfonylurea on colorectal...
Read MoreAberrant FAM135B attenuates the efficacy of chemotherapy in colorectal cancer by modulating SRSF1-mediated alternative splicing.
Oxaliplatin is the frontline chemotherapy drug for the treatment of colorectal cancer (CRC) and its insensitivity is a major limitation on therapeutic efficacy. Genomic instability is the prominent feature of CRC and is...
Read MoreUSP36 promotes colorectal cancer progression through inhibition of p53 signaling pathway via stabilizing RBM28.
Colorectal cancer (CRC) stands as the second most common cause of cancer-related mortality globally and p53, a widely recognized tumor suppressor, contributes to the development of CRC. Ubiquitin-specific protease 36 (USP36),...
Read MoreAssociation between pathological T1 colorectal cancer with lymphoid follicular replacement and risk of lymph node metastasis.
Endoscopic resection (ER) is widely performed to treat early colorectal cancer. However, additional surgery for pathological T1 colorectal cancer (pT1CRC) after ER is controversial because of the imprecise prediction of lymph...
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