A Comparative Study of Patient-Reported Abdominal Pain in Oxaliplatin-Based PIPAC-OX and Primary Colorectal Cancer Surgery
The following is a summary of “Comparing patient reported abdominal pain between patients treated...
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Showing 1 - 20 of 1969 results for 'colorectal cancer '
Receipt of Guideline-Concordant Care Lower for Black Colorectal Cancer Patients
TUESDAY, Nov. 14, 2023 (HealthDay News) — Individuals racialized as Black and newly...
Read MoreCircRNA circ_0013339 Regulates the Progression of Colorectal Cancer Through miR-136-5p/SOX9 Axis.
Colorectal cancer (CRC) is a common gastrointestinal malignancy. Dysregulation of circular RNAs (circRNAs) is associated with the progression of CRC. However, the role of circ_0013339 (hsa_circ_0013339) in CRC is still not...
Read MoreEvaluating the potential impact of lifestyle-based behavior change interventions delivered at the time of colorectal cancer screening.
To analyze interventions implemented at the time of colorectal cancer (CRC) screening, or among individuals who have previously undergone investigation for CRC, focused on reducing CRC risk through promotion of lifestyle...
Read MorePredicting Colorectal Cancer Survival Using Time-to-Event Machine Learning: Retrospective Cohort Study.
Machine learning (ML) methods have shown great potential in predicting colorectal cancer (CRC) survival. However, the ML models introduced thus far have mainly focused on binary outcomes and have not considered the time-to-event...
Read MoreThe effect of continuous care on the recovery of patients with advanced colorectal cancer undergoing chemotherapy.
To explore the impact of continuous care on chemotherapy patients with advanced colorectal cancer. Six hundred forty patients who received chemotherapy from June 2015 to December 2022 were included in this retrospective study...
Read MoreInhibition of thioredoxin-1 enhances the toxicity of glycolysis inhibitor 2-deoxyglucose by downregulating SLC1A5 expression in colorectal cancer cells.
Targeting glycolysis in cancer is an attractive approach for therapeutic intervention. 2-Deoxyglucose (2DG) is a synthetic glucose analog that inhibits glycolysis. However, its efficacy is limited by the systemic toxicity at...
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Impact of Behavioral Interventions on Colonoscopy Uptake for Colorectal Cancer Screening
The following is a summary of “Effect of Behavioral Interventions on the Uptake of...
Read More“We’re trained to trust our patients”: a qualitative study on the general practitioners’ trust in patients for colorectal cancer shared care.
In a therapeutic partnership, physicians rely on patients to describe their health conditions, join in shared decision-making, and engage with supported self-management activities. In shared care, the patient, primary care, and...
Read MoreLIMK1 mA-RNA methylation recognized by YTHDC2 induces 5-FU chemoresistance in colorectal cancer via endoplasmic reticulum stress and stress granule formation.
LIM kinase 1 (LIMK1) is a member of the LIMK family that has been considered to be involved in chemoresistance in various tumors, and N-methyladenosine (mA) is the most abundant nucleotide modification on mRNA. However, whether...
Read MoreValidating the role of PTGIS gene in colorectal cancer by bioinformatics analysis and in vitro experiments.
Prostaglandin I2 synthase (PTGIS) is a member of the cytochrome P450 family. Studies have revealed that differential expression of the PTGIS gene is closely related to the pathological and physiological processes of many...
Read MoreScreening and identifying of biomarkers in early colorectal cancer and adenoma based on genome-wide methylation profiles.
Colorectal cancer is one of the most common malignant tumors worldwide with high morbidity and mortality. This study aimed to identify different methylation sites as new methylation markers in CRC and colorectal adenoma through...
Read MoreComparison of immediate germline sequencing and multi-step screening for Lynch syndrome detection in high-risk endometrial and colorectal cancer patients.
Lynch syndrome (LS) is a hereditary cancer predisposition syndrome with a significantly increased risk of colorectal and endometrial cancers. Current standard practice involves universal screening for LS in patients with newly...
Read MoreACVRL1 drives resistance to multitarget tyrosine kinase inhibitors in colorectal cancer by promoting USP15-mediated GPX2 stabilization.
Multitarget tyrosine kinase inhibitors (mTKIs) such as Regorafenib and Sorafenib have already been approved for the treatment of many solid tumours. However, the efficacy of mTKIs in colorectal cancer (CRC) is limited; the...
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Advanced Young-Onset Adenoma Increases Colorectal Cancer Risk
MONDAY, Sept. 18, 2023 (HealthDay News) — Advanced young-onset adenoma (YOA) increases the...
Read MoreA history of bariatric surgery before surgery for colorectal cancer may improve short-term postoperative outcomes: Analysis of the national inpatient sample 2015-2019.
Bariatric surgery is the most effective and sustainable form of weight loss. Bariatric surgery before elective operations for colorectal pathology may improve postoperative outcomes. To compare patients with and without prior...
Read MoreDynamics of colorectal cancer screening in low and middle-income countries: A modeling analysis from Thailand.
Low and middle-income countries face constraints for early colorectal cancer (CRC) detection, including restricted access to care and low colonoscopy capacity. Considering these constraints, we studied strategies for increasing...
Read MoreAllyl-isothiocyanate against colorectal cancer via the mutual dependent regulation of p21 and Nrf2.
Allyl-isothiocyanate (AITC) is a common Isothiocyanates (ITC) and its chemo-preventive and anti-tumor effects are believed to be related to the activation of NF-E2 p45-related Factor 2 (Nrf2). However, its anti-tumor effects on...
Read MoreTCAF2 in Pericytes Promotes Colorectal Cancer Liver Metastasis via Inhibiting Cold-Sensing TRPM8 Channel.
Hematogenous metastasis is the main approach for colorectal cancer liver metastasis (CRCLM). However, as the gatekeepers in the tumor vessels, the role of TPCs in hematogenous metastasis remains largely unknown, which may be...
Read MoreCurcumin inhibits malignant behavior of colorectal cancer cells by regulating M2 polarization of tumor-associated macrophages and metastasis associated in colon cancer 1 (MACC1) expression.
The present study was to investigate the underlying mechanism of the antitumor effect of curcumin in colorectal cancer cells, focusing on the M2 polarization of tumor-associated macrophages (TAMs). The effect of curcumin on the...
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