This study aimed to compare the impact of Cyclofem and DMPA on endometrial vascular density, endometrial histology, and way of bleeding.

Sixty-eight women were randomly assigned to Cyclofem (38 women) or DMPA (30 women). Endometrial vascular density significantly decreased to 132.4 ± 12.2 after DMPA use, and from 151.9 ± 5.8 to 131.8 ± 12.8 vessels/mm2 following Cyclofem service. However, there was no significant difference between endometrial vascular density during treatment with Cyclofem or DMPA. Total bleeding days in the first and second 3-month time intervals were 28 ± 23 and 18 ± 12 days in DMPA users and 22 ± 14 and 16 ± nine days in Cyclofem users, respectively; spotting was the most common type of bleeding experienced. Atrophic endometrium was the most common histological pattern observed in both groups.

This study concluded that both Cyclofem and DMPA use are associated with decreased endometrial vascular density and atrophic endometrium, in addition to irregular bleeding, mainly spotting. There was no significant difference in bleeding patterns or endometrial findings observed for these two injectable contraceptives in Iranian women.