Laugier‐Hunziker syndrome, also known as LHS, is an infrequent, idiopathic pigmentary disorder. It affects the lips and oral mucosa primarily. Until now, doctors have diagnosed only 200 patients with LHS syndrome worldwide. And till now, only three patients under the age of 20 were described. That included the youngest patient, who was only a 12‐year‐old child. The exact etiology of Laugier‐Hunziker syndrome remains unpredictable, as there is no evidence of systemic symptoms or increased cancer risk. The final diagnosis of LHS is possible after excluding other, more severe diseases involving skin‐mucosal hyperpigmentation, mainly Peutz‐Jeghers syndrome or PJS and Addison’s disease or AD. Herein, we present a 16‐year‐old patient who has been diagnosed with oral hyperpigmentation since the age of 13. The doctors and researchers have reviewed the clinical and histological findings. In addition, they have also discussed the differential diagnosis of mucocutaneous hyperpigmentation.

You have seen that the number of patients with Laugier‐Hunziker syndrome is significantly less compared to other diseases. Therefore the doctors and researchers are continuing the study over and over again to find some new outcomes from the cases. They are examining every available data thoroughly to come out to a new conclusion.

Ref: https://onlinelibrary.wiley.com/doi/10.1111/ijd.15262

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