This review aims to provide a comprehensive analysis of the current literature regarding the use of CellaVision digital morphology systems and to assess the emerging applications, their potential to supplement current diagnostic pathways, and-importantly-appreciate their practical and perceived limitations.
A manual literature review was conducted to identify relevant journal articles and published abstracts as they relate to the application of CellaVision systems to hematology laboratory practice in human patients.
CellaVision systems can characterize cellular morphology with overall a high degree of accuracy-in particular, for neutrophils; lymphocytes; and common red blood cell changes, including target cells. Challenges remain, however, with the detection of particular important findings, including immature granulocytes and red blood cell agglutination. The application of CellaVision systems to emerging areas such as telepathology and parasitology are evolving, with an increasing volume of literature highlighting the technology’s utility.
CellaVision systems and associated digital technologies are poised to play an increasingly important role in hematology laboratories, with promises of enhanced accuracy and improved workflows. Several critical deficiencies highlight the necessity for continued research to support their transition into routine clinical practice.

© American Society for Clinical Pathology, 2025.