Atopic disorders, such as atopic dermatitis, allergic rhinitis, and asthma are inflammatory diseases that affect many children. For this study, scientists looked into whether these inflammatory atopic illnesses in children were linked to anemia. In 2016, researchers undertook a cross-sectional analysis with a pediatric dataset from South Korea’s Health Insurance Review and Assessment Service (HIRA). The connection between atopic illness and iron deficiency anemia was investigated using multivariable logistic regression with demographic factors adjusted (IDA). The study covered a total of 846,718 pediatric patients. 

A total of 19,594 (2.31%) had been diagnosed with IDA. Atopic dermatitis had an adjusted OR of 1.42 (95% CI, 1.37–1.47), allergic rhinitis had an adjusted OR of 1.25 (95% CI, 1.21–1.29), and asthma had an adjusted OR of 1.71 (95% CI, 1.65–1.76). Patients with multiple concomitant atopic disorders were more likely to have IDA, with aORs of 1.30 (95% CI, 1.25–1.35), 1.81 (95% CI, 1.73–1.89), and 2.58 (95% CI, 2.43–2.73) for 1, 2, or 3 atopic diagnoses, respectively. There was no evidence of covariate multicollinearity. The findings imply that IDA is linked to atopic illness. More research is needed to understand better the origin of anemia in individuals with inflammatory disorders to elucidate the difference between IDA and AI.

Reference:bmcpediatr.biomedcentral.com/articles/10.1186/s12887-019-1836-5