For a study, it was determined that other immune-mediated illnesses were frequently present in both atopic dermatitis and celiac disease. Researchers had to see if there was a link between atopic dermatitis and celiac disease in a large community-based sample. The study employed a cross-sectional observational design. Patients diagnosed with atopic dermatitis by a dermatologist between 2002 and 2017 were enrolled in a big health management organization, and demographic and clinical data were gathered. For the overall population, adults (age>18 years), and adults with moderate-to-severe atopic dermatitis, the occurrence of celiac disease/celiac disease-related morbidities was documented. The results were compared to those of a matched control group that did not have atopic dermatitis. 

There were 116,816 patients in the trial, 45,157 of them were adults, and 1,909 of them had moderate-to-severe atopic dermatitis. The prevalence rate of celiac disease was 0.6% vs. 0.4% in the overall sample, 0.6% vs. 0.3% in adults, and 0.8% vs. 0.3% in adults with moderate-to-severe atopic dermatitis (P<0.001 for all). In multivariate analysis, atopic dermatitis was linked to a substantially higher prevalence of celiac disease in the overall study population and each subgroup (odds ratio = 1.609, 95% CI 1.42–1.82, P<0.001).

A substantial link between atopic dermatitis and celiac disease was discovered.