For a study, researchers sought to develop and pilot-test the PREparing Patients for Active Involvement in Medication Review (PREPAIR) tool, a questionnaire-based preparation and discussion tool to encourage patients with polypharmacy to participate in medication optimization in general practice. To create the tool, investigators studied the literature before engaging in a co-production process that included a workshop with 6 general practitioners and pilot testing involving 22 patients, 3 GPs, and 3 practice staff members. They continuously modified the prototype throughout this procedure. The development process and mechanisms of influence were the main topics of their theme analysis of the qualitative data. The final PREPAIR tool had 5 sections: adverse drug reactions; excess medication, needless medication; medication satisfaction, and medication-related problems to discuss with the GP (open-ended question). The patient completed the PREPAIR instrument at home to promote reflection on the medicine and presented it to the GP consultation. It was the applicable workflow during testing. The doctor evaluated the patient’s responses during the appointment and discussed potential medication-related issues. For several patients, the increased introspection led to worries about the drugs. But the pilot testing revealed that when patients used the PREPAIR program, they arrived at the clinic well-PREPAIR and were confident in their ability to talk. The GPs gained a better grasp of the patients’ viewpoints from the PREPAIR-supported discourse, which helped them deliver a more patient-centered consultation. Despite some patients’ early concerns, the PREPAIR-supported discourse ultimately helped them feel more secure, satisfied, and knowledgeable about their medication. Study group created a simple instrument to enhance active patient involvement in medication review in general practice. Patients and general practitioners were pleased with the PREPAIR tool, which also worked well in the current clinical practice. According to their research, the PREPAIR tool can encourage patient participation during consultations and promote patient-centered care.