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A genetic variant in IL-15Rα correlates with physical activity among European-American adults.

A genetic variant in IL-15Rα correlates with physical activity among European-American adults.
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Bruneau M, Walsh S, Selinsky E, Ash G, Angelopoulos TJ, Clarkson P, Gordon P, Moyna N, Visich P, Zoeller R, Thompson P, Gordish-Dressman H, Hoffman E, Devaney J, Pescatello LS,


Bruneau M, Walsh S, Selinsky E, Ash G, Angelopoulos TJ, Clarkson P, Gordon P, Moyna N, Visich P, Zoeller R, Thompson P, Gordish-Dressman H, Hoffman E, Devaney J, Pescatello LS, (click to view)

Bruneau M, Walsh S, Selinsky E, Ash G, Angelopoulos TJ, Clarkson P, Gordon P, Moyna N, Visich P, Zoeller R, Thompson P, Gordish-Dressman H, Hoffman E, Devaney J, Pescatello LS,

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Molecular genetics & genomic medicine 2018 04 06() doi 10.1002/mgg3.368
Abstract
BACKGROUND
Interleukin-15 (IL-15) is a myokine associated with muscle strength, possibly by attenuating protein breakdown. A variant in the alpha-receptor (IL-15Rα 1775 A>C, rs2228059) partially modulates the muscle strength and size response to resistance training. We examined if this polymorphism associated with habitual physical activity among European-American adults.

METHODS
Men (n = 240, 23.7 ± 0.3 year, body mass index [BMI] 25.3 ± 0.3 kg/m) and women (n = 292, 23.2 ± 0.3 year, 24.0 ± 0.3 kg/m) were genotyped. Physical activity phenotypes were derived from the Paffenbarger Physical Activity Questionnaire. Analysis of covariance (ancova) tested log-transformed differences between the IL-15Rα genotype and physical activity phenotypes by gender with age and BMI as covariates.

RESULTS
Men with the IL-15Rα 1775AA genotype spent more time in light intensity physical activity (39.4 ± 2.4 hr/week) than men with the CC genotype (28.6 ± 2.3 hr/week, (p = .009).

CONCLUSION
Further research is needed to confirm our finding and determine the possible mechanisms by which the IL-15Rα variant modulates light intensity physical activity.

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