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A Novel Recombinant Form of HIV-1 CRF01_AE/CRF07_BC Identified by Near Full-Length Genome in Shaanxi, China.

A Novel Recombinant Form of HIV-1 CRF01_AE/CRF07_BC Identified by Near Full-Length Genome in Shaanxi, China.
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Zhang M, Xin R, Chang W,


Zhang M, Xin R, Chang W, (click to view)

Zhang M, Xin R, Chang W,

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AIDS research and human retroviruses 2017 10 23() doi 10.1089/AID.2017.0186

Abstract

Recently multiple kinds of unique recombinant forms of HIV-1 CRF01_AE/CRF07_BC were identified in China. In this study, we report another near full-length genome of a novel recombinant form (SN121) between CRF01_AE and CRF07_BC from an HIV-1-infected male through heterosexual behavior in Shaanxi province, China. The analysis of SN121 showed that the genome composed of seven interlaced segments, including three CRF07_BC and four CRF01_AE segments with CRF01_AE as the backbone. Six breakpoints were observed in the pol and env gene regions, which are different from the previously identified CRF01_AE/07_BC recombinant forms in China. This novel emerging recombinant form suggested the complicated genetic diversity and the active local transmission of HIV-1 in Shaanxi province. Further monitoring should be performed to elucidate the possible molecular evolution of this novel recombinant form.

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