Human papillomavirus (HPV) causes a variety of malignancies that disproportionately impact Latinos, yet there has been little study on strategies to boost HPV vaccination among this group. Researchers wanted to see how a web-based, individually customised intervention called CHICOs (Combatting HPV Infection and Cancers, personalised intervention) affected HPV vaccination use. From June 2014 to February 2016, they performed a three-arm, randomised, controlled study in the waiting rooms of five family medical practises, comparing CHICOS against an iPad-based version of the Centers for Disease Control and Prevention’s Vaccine Information Sheet and usual care. Pairwise comparisons of 6 distinct metrics of HPV vaccination uptake were made between trial arms, with analyses stratified by adolescents vs young adults. There were 1,013 people who could be vaccinated out of the 1,294 people who took part in the research. During the research period, 265 adolescents, but only 18 young adults, got an HPV vaccination dosage across study arms. There were essentially no differences in any vaccination measure between the CHICOS and untailored arms, or between the untailored or CHICOS arms and usual care.

According to the findings, a targeted educational intervention may not be helpful in improving HPV vaccination uptake among Latino adolescents or young adults. However, the study’s statistical power may have been reduced since study participants had greater than predicted baseline levels of favourable vaccination views.