Advertisement

 

 

A randomized controlled study on the efficacy of a novel combination vaccine against enzootic pneumonia (Mycoplasma hyopneumoniae) and porcine Circovirus type 2 (PCV2) in the presence of strong maternally derived PCV2 immunity in pigs.

A randomized controlled study on the efficacy of a novel combination vaccine against enzootic pneumonia (Mycoplasma hyopneumoniae) and porcine Circovirus type 2 (PCV2) in the presence of strong maternally derived PCV2 immunity in pigs.
Author Information (click to view)

Tassis PD, Tsakmakidis I, Papatsiros VG, Koulialis D, Nell T, Brellou G, Tzika ED,


Tassis PD, Tsakmakidis I, Papatsiros VG, Koulialis D, Nell T, Brellou G, Tzika ED, (click to view)

Tassis PD, Tsakmakidis I, Papatsiros VG, Koulialis D, Nell T, Brellou G, Tzika ED,

Advertisement

BMC veterinary research 2017 04 0713(1) 91 doi 10.1186/s12917-017-1014-7
Abstract
BACKGROUND
Mycoplasma hyopneumoniae (M. hyo) and Porcine Circovirus Type 2 (PCV2) are major pathogens that cause significant health problems in swine worldwide. Maternal derived immunity (MDI) has been suggested as a significant immediate defence factor for newborn piglets and may interfere with piglet’s vaccination-induced immunity. The study aimed to assess the efficacy of a novel combination vaccine (consisting of PCV2 subunits and inactivated M. hyo strain J), against PCV2 and M. hyo natural infection [Porcilis(®) PCV M Hyo (MSD Animal Health, Boxmeer, the Netherlands)], in the presence of strong maternally derived PCV2 immunity (antibody titre averaged 11.08 log2), under field conditions. The study was performed according to a controlled, randomized and blinded design in a Greek swine unit with Enzootic Pneumonia (EP) and subclinical PCV2 infection. In total, 600 healthy three-week-old suckling piglets were allocated randomly, either to treatment (vaccinated with the test product) or control group (injected with sterile buffered saline).

RESULTS
Vaccination significantly reduced the severity of lung lesions at slaughter (lesions of cranio-ventral pulmonary consolidation) (P < 0.001). The overall mean lung lesion score (LLS) was 9.6 in the vaccinated group and 12.2 in controls. The level of PCV2 viraemia was significantly reduced in vaccinated pigs. Furthermore, 25 g higher average daily weight gain (ADWG) was observed during the finishing phase (P < 0.001) and 18 g greater ADWG overall (P < 0.001). CONCLUSIONS
Results of LLS, PCV2 viremia and ADWG support the test product’s efficacy in the face of strong maternally derived PCV2 immunity.

Submit a Comment

Your email address will not be published. Required fields are marked *

eleven + twelve =

[ HIDE/SHOW ]