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A Rare Monocytic Crisis of Chronic Myelogenous Leukemia Presenting with Unusual Extramedullary Manifestations and an Atypical (14;22)(q24;q11.2) Translocation in the Bone Marrow.

A Rare Monocytic Crisis of Chronic Myelogenous Leukemia Presenting with Unusual Extramedullary Manifestations and an Atypical (14;22)(q24;q11.2) Translocation in the Bone Marrow.
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Inoue M, Hagihara M, Uchida T, Hua J, Nakajima T, Tajima S, Ota Y,


Inoue M, Hagihara M, Uchida T, Hua J, Nakajima T, Tajima S, Ota Y, (click to view)

Inoue M, Hagihara M, Uchida T, Hua J, Nakajima T, Tajima S, Ota Y,

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Internal medicine (Tokyo, Japan) 2017 10 11() doi 10.2169/internalmedicine.8617-16
Abstract

A 48-year-old man was admitted due to marked leukocytosis. Bone marrow examinations resulted in a diagnosis of Philadelphia (Ph) chromosome-positive chronic myeloid leukemia. One month later, massive muscle and bone invasion by leukemic cells was detected. After induction chemotherapy, he complained of a headache and visual loss, which was caused by a leukemic infiltration in the central nervous system. After temporary remission in response to chemotherapy, the disease relapsed in the form of an intracranial tumor. The unusual t(14;22)(q24;q11.2) translocation of the Ph-chromosome and the significant increase in monocytes observed might have contributed to the unique and aggressive clinical course.

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