GSD or Gorham-Stout disease is an idiopathic bone disorder caused by massive osteolysis. Until now, there is no established treatment strategy for GSD. The high-level doctors and researchers empirically treated two patients who suffered from cranial lesions of GSD. This study’s main objective is to propose a novel algorithm to manage Gorham’s disease based on experiences. They have reviewed all existing studies on GSD describing the pathophysiology and suggested treatment methods up to 2018.

They found around 12 to 13 papers with 16 recorded cases of GSD involving the skull. Of those, the skull base was affected in eight cases. On the other side, the remaining eight cases showed cranial involvement. The patients with skull-base participation were managed conservatively, using medications or radiotherapy. The patients with cranial osteolysis were managed surgically, with excision of the osteolytic portion, followed by cranioplasty. Of the latter group, the pericranium was not removed in one patient, in whom a very slight progression of the osteolytic process was later observed. Apart from those 16 cases, the researchers are still looking for new cases to learn more about Gorham-Stout disease. However, this case is already one of the rarest cases in the whole world.