Drug hypersensitivity responses (DHRs) to intravenous medications could be severe and force patients and medical professionals to postpone a necessary therapy or intervention. Even though almost every intravenous medication had the potential to cause a fatal DHR, chemotherapeutics, biologics, and antibiotics were among the ones that caused severe responses the most frequently. Of course, stopping such medicines could have a bad effect on the chances of survival or the standard of living for the affected individuals. Reactive patients could be kept on first-choice medications rather than switching to less effective, more expensive, or harmful substitutes using relabeling pathways and rapid drug desensitization (RDD). To ensure safety, an accurate diagnosis and individualized care, this high-complexity, and high-risk approach typically require specialist teams and allergy-specific techniques (skin testing, in vitro testing, drug provocation testing). Unfortunately, there were large disparities in access to allergy departments with the knowledge and resources to provide these approaches and effectively address these DHRs within and between nations. The fundamental goal of this consensus agreement was to greatly benefit patients everywhere by assisting allergists in broadening the area of their practice and supporting them with research, information, and expertise from top international organizations. This declaration from the World Allergy Organization’s (WAO) Drug Hypersensitivity Committee seeks to serve as a thorough practical reference on the technical elements of implementing acute-onset intravenous hypersensitivity relabeling and RDD for a variety of medicines. The manuscript does not solely concentrate on clinical routes, as a result. Instead, it also offered advice on subjects that were typically ignored, such as internal validation, ongoing quality improvement, building a positive multidisciplinary atmosphere, and reinventing treatment (including a specific supplemental section on a real-life example of how to design a dedicated space that could combine basic and complex diagnostic and therapeutic techniques in allergy).