Atopic dermatitis/eczema, contact dermatitis, and medication hypersensitivity are all examples of allergic skin disorders. Allergic skin disorders are quite common. Atopic dermatitis is a prevalent inflammatory skin condition that is comparable to allergic rhinitis and allergic asthma. For a long time, allergy disorders were thought to be T-helper-2 (Th2)-mediated by immunoglobulin E. However, novel cytokines and T cells have been identified in recent years. The emphasis of this systematic study is on interleukin-17 and the interleukin-20 family, which appear to be fine-tuning the Th2-driven response. T cells generate IL-17, which is a proinflammatory cytokine. IL-17 is primarily generated by activated CD4+ cells known as Th-17 cells. IL-17 controls the production of adhesion molecules and chemokines by keratinocytes. IL-17 has a role in the development of inflammatory illnesses such as psoriasis, arthritis, and inflammatory bowel disease. The role of the TH17/IL17-pathway in allergic disorders has just lately been described. In terms of allergic inflammatory diseases, IL-22 is the most intriguing and researched cytokine in the IL-20 family. T-helper 22 cells, a novel subgroup of CD4+ cells, generate IL-22.
Both IL-17 and IL-22 appear to have a role in the development of allergic skin disorders.
