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A Unique Second-Generation Recombinant Form of HIV-1 Identified Among Men Who Have Sex with Men Population in Beijing, China.

A Unique Second-Generation Recombinant Form of HIV-1 Identified Among Men Who Have Sex with Men Population in Beijing, China.
Author Information (click to view)

Li X, Hao M, Hao Y, Ye J, Xin R, Lu H,


Li X, Hao M, Hao Y, Ye J, Xin R, Lu H, (click to view)

Li X, Hao M, Hao Y, Ye J, Xin R, Lu H,

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AIDS research and human retroviruses 2017 07 05() doi 10.1089/AID.2017.0102

Abstract

In China, CRF01_AE and CRF07_BC are the most circulating strains of HIV-1, more and more second-generation recombinant forms have been isolated around the two strains. The same situation happened in Beijing in recent years. In our study, we have isolated a new second-generation recombinant form of HIV-1 from a male patient who was infected by homosexual behavior. Polygenetic analysis revealed that the sequence includes five CRF01_AE fragments and four CRF07_BC fragments. CRF01_AE is the skeleton of the recombinant which was inserted with four CRF07_BC fragments. The emergency of such second-generation recombinant forms manifests the diversity of the HIV-1 epidemic. Consequently, further investigation of molecular epidemiology is needed to track the genetic evolution of HIV-1.

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