TUESDAY, May 5, 2020 (HealthDay News) — People with low mood and those with a history of depression may be less able to stabilize mood via mood-modifying activities, according to a study published online April 22 in JAMA Psychiatry.

Maxime Taquet, B.M.B.Ch., Ph.D., from University of Oxford in the United Kingdom, and colleagues calculated the quantitative association between mood and daily activities in two large case-control studies: the 58sec data set (collected from Dec. 1, 2012, to May 31, 2014, with 28,212 participants in high-income countries) and the World Health Organization Study on Global Aging and Adult Health (WHO SAGE) data set (collected from Jan. 1, 2007, to Dec. 31, 2010, with 30,116 participants in low- and middle-income countries).

The researchers found that mood homeostasis (defined as the stabilization of one’s mood by engaging in mood-modifying activities) was significantly lower in people with low (versus high) mean mood and in people with (versus without) a history of depression. Lower mood homeostasis led to more depressive episodes (11.8 versus 3.8 percent yearly risk) that lasted longer (4.19 versus 2.90 weeks) in dynamic simulations.

“Additional studies are needed to demonstrate a causal link between mood homeostasis and depression,” the authors write. “We believe our findings thus open the door to new research avenues that may ultimately help reduce the disease burden of depression.”

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