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Acute coronary syndromes in patients with HIV.

Acute coronary syndromes in patients with HIV.
Author Information (click to view)

Seecheran VK, Giddings SL, Seecheran NA,


Seecheran VK, Giddings SL, Seecheran NA, (click to view)

Seecheran VK, Giddings SL, Seecheran NA,

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Coronary artery disease 28(2) 166-172 doi 10.1097/MCA.0000000000000450

Abstract

Highly active antiretroviral treatment (HAART) has considerably increased the life expectancy of patients infected with HIV. Coronary artery disease is a leading cause of mortality in patients infected with HIV. This is primarily attributed to their increased survival, HAART-induced metabolic derangements, and to HIV itself. The pathophysiology of atherosclerosis in HIV is both multifactorial and complex – involving direct endothelial injury and dysfunction, hypercoagulability, and a significant contribution from traditional cardiac risk factors. The advent of HAART has since heralded a remarkable improvement in outcomes, but at the expense of other unforeseen issues. It is thus of paramount importance to swiftly recognize and manage acute coronary syndromes in HIV-infected patients to attenuate adverse complications, which should translate into improved clinical outcomes.

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