Prognostic Scores Validated for Additional Mutations in Secondary Myelofibrosis
Adding additional clinical and genetic information improved the performance of prognostic scores in secondary myelofibrosis, researchers in France report.
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Triple-Negative Myelofibrosis Shows Aggressive Behavior, Poor Outcomes
Triple-negative myelofibrosis affects 6% of myelofibrosis patients and is marked by aggressive clinical behavior and poor outcomes.
Read MoreMutations & Proliferative Pathways Drive Myelofibrosis Evolution
Myeloproliferative neoplasms (MPN) are marked by the overproduction of myeloid cells, driven by JAK2, CALR, and MPL mutations. A recent study aimed to explain how these mutations result in various MPN phenotypes by sequencing...
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Anti-T-Lymphocyte Globulin Improves Survival Post-AlloHCT in Patients With Myelofibrosis
Anti-T-lymphocyte globulin significantly reduced the risk of GvHD, relapse, or death by 48%, enhancing GRFS, especially in matched donor transplants.
Read MoreMF Grade Does Not Impact Prognosis in Patients With MDS
Myelodysplastic syndrome (MDS) is a complex hematological malignancy, often presenting with myelofibrosis (MF) in 10% to 20% of cases. Although MF is recognized as an independent risk factor for MDS prognosis, it is not...
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