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Adipocytokines in obese Ghanaian subjects with or without type 2 diabetes.

Adipocytokines in obese Ghanaian subjects with or without type 2 diabetes.
Author Information (click to view)

Adams Y, Ofori EK, Asare-Anane H, Amanquah SD, Ababio GK, Abendau E, Nabia R,


Adams Y, Ofori EK, Asare-Anane H, Amanquah SD, Ababio GK, Abendau E, Nabia R, (click to view)

Adams Y, Ofori EK, Asare-Anane H, Amanquah SD, Ababio GK, Abendau E, Nabia R,

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BMC research notes 2018 02 0811(1) 109 doi 10.1186/s13104-018-3149-4
Abstract
OBJECTIVE
This study aimed to evaluate serum leptin and high sensitivity C-reactive protein (hsCRP) concentrations in obese Ghanaians with or without type 2 diabetes and to find out the extent to which their levels are influenced by underlying disorders.

RESULTS
Obese subjects with type 2 diabetes had lower leptin but higher hsCRP levels compared with obese non-diabetic controls. There were negative correlations within the control group for glucose vs % muscle mass (r = – 0.378, p = 0.016), leptin vs % muscle mass (r = – 0.555, p = 0.001) and within the obese diabetic group for leptin vs % muscle mass (r = – 0.602, p = 0.001). Obese persons without diabetes were about three times more likely to have higher leptin levels compared with their obese diabetic counterparts (Odds ratio = 3.315, p < 0.001). Obese females independently had a tenfold increase in leptin levels compared with obese males.

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