Adiposity is referred to as the condition of being severely overweight or obese. Adiposity or severe obesity has been linked to several health conditions, like diabetes and increased risk of cardiovascular events. Some evidence also suggests the risk of a decline in glomerular filtration rate (GFR), but there’s not enough research to support the claim. The objective of this study is to derive associations between adiposity and the risk of decline and GFR and with all-cause mortality.

This is an individual participant data meta-analysis that included a total of 594,496 participants with data on waist circumference, 84,417 participants at risk of cardiovascular disease, and 91,607 at the risk of chronic kidney disease. The primary outcomes were GFR decline, initiation of kidney replacement therapy, and all-cause mortality.

During the mean follow-up of eight years, a total of 246,607 (5.6%) individuals in the general population cohorts had GFR decline, and 782,329 (14.7%) deaths were reported. The multivariable analysis suggested that the decline in GFR at BMI 30,35, and 40, compared with BMI 25, were 1.18, 1.69, and 2.02, respectively.

The research suggested that elevated body mass index and waist circumference was associated with a higher risk of GFR decline and all-cause mortality.