The following is a summary of “Effects of Coenzyme Q10 Supplementation on Lipid Profiles in Adults: A Meta-analysis of Randomized Controlled Trials,” published in the January 2023 issue of Endocrinology & Metabolism by Liu, et al.

The effects of coenzyme Q₁₀ (CoQ₁₀) on lipid profiles are still up for debate, according to earlier meta-analyses. Furthermore, no meta-analysis looked at the best CoQ₁₀ dosage for lowering adult lipid profiles. For a study, researchers used a meta-analysis to examine the dose-response relationships of CoQ₁₀ in adults and its impact on lipid profiles.

The Cochrane Library, Web of Science, PubMed/Medline, Embase, and these other databases were all thoroughly searched till August 10, 2022. To determine the mean differences (MDs) and 95% confidence intervals (CI) for changes in circulating lipid profiles, the random effects model was utilized. To examine nonlinear dose-response relationships, a brand-new single-stage limited cubic spline regression model was used.

The qualitative synthesis comprised a total of 2,794 people from 50 randomized controlled studies. According to the pooled analysis, supplementing with CoQ₁₀ significantly lowered total cholesterol (TC) (MD −5.53 mg/dL; 95% CI −8.40, −2.66; I² = 70%), low-density lipoprotein cholesterol (LDL-C) (MD −3.03 mg/dL; 95% CI −5.25, −0.81; I² = 54%), and triglycerides (TGs)  (MD −9.06 mg/dL; 95% CI −14.04, −4.08; I² = 65%) and increased high-density lipoprotein cholesterol (HDL-C) (MD 0.83 mg/dL; 95% CI 0.01, 1.65; I² = 82%). The inverse J-shaped nonlinear relationship between CoQ₁₀ supplementation and TC was evident in the dose-response analysis, where 400–500 mg/day of CoQ₁₀ significantly decreased TC (χ² = 48.54, P < .01).

Adults using CoQ₁₀ supplements saw reductions in their TC, LDL-C, and TG levels as well as an increase in HDL-C levels. The highest impact on TC was shown at doses of 400 to 500 mg/day.

Reference: academic.oup.com/jcem/article-abstract/108/1/232/6751027?redirectedFrom=fulltext