Advertisement

 

 

Aging and adipose tissue: potential interventions for diabetes and regenerative medicine.

Aging and adipose tissue: potential interventions for diabetes and regenerative medicine.
Author Information (click to view)

Palmer AK, Kirkland JL,


Palmer AK, Kirkland JL, (click to view)

Palmer AK, Kirkland JL,

Advertisement
Share on FacebookTweet about this on TwitterShare on LinkedIn

Experimental gerontology 2016 02 2686() 97-105 pii S0531-5565(16)30054-7
Abstract

Adipose tissue dysfunction occurs with aging and has systemic effects, including peripheral insulin resistance, ectopic lipid deposition, and inflammation. Fundamental aging mechanisms, including cellular senescence and progenitor cell dysfunction, occur in adipose tissue with aging and may serve as potential therapeutic targets in age-related disease. In this review, we examine the role of adipose tissue in healthy individuals and explore how aging leads to adipose tissue dysfunction, redistribution, and changes in gene regulation. Adipose tissue plays a central role in longevity, and interventions restricted to adipose tissue may impact lifespan. Conversely, obesity may represent a state of accelerated aging. We discuss the potential therapeutic potential of targeting basic aging mechanisms, including cellular senescence, in adipose tissue, using type II diabetes and regenerative medicine as examples. We make the case that aging should not be neglected in the study of adipose-derived stem cells for regenerative medicine strategies, as elderly patients make up a large portion of individuals in need of such therapies.

Submit a Comment

Your email address will not be published. Required fields are marked *

sixteen − fourteen =

[ HIDE/SHOW ]