AHA Scientific Sessions 2012: Experimental Combination Drug Yields Cardiovascular Benefits


The Particulars: Researchers believe that fixed-dose combination therapy for cardiovascular disease could improve the control of risk factors by enhancing medication adherence. Evidence, however, is lacking in the testing of this hypothesis.

Data Breakdown: For a study, 2,004 patients were randomized to combination therapy with aspirin 75 mg, simvastatin 40 mg, lisinopril 10 mg, and atenolol 50 mg or to usual care. After 15 months, 86% of patients were adherent to the combination, compared with 65% of usual care patients. Patients receiving combination therapy had an average systolic blood pressure (BP) of 129.2 mm Hg and an average LDL cholesterol level of 2.18 mmol/L. This compared favorably to usual care patients, who averaged a systolic BP of 131.7 mm Hg and an LDL cholesterol level of 2.29 mmol/L.

Take Home Pearls: A fixed-dosed combination tablet containing aspirin, a statin, and two antihypertensive agents appears to improve treatment adherence when compared with usual care. In addition, the combination drug was shown to significantly reduce LDL cholesterol and BP.


  1. AHA Scientific Sessions 2012 | Physician's Weekly - [...] Experimental Combination Drug Yields Cardiovascular Benefits [...]

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