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Aliskiren reduces albuminuria after kidney transplantation.

Aliskiren reduces albuminuria after kidney transplantation.
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Tylicki L, Debska-Slizien AM, Lizakowski S, Przybylska M, Heleniak Z, Renke M, Chamienia AL, Biedunkiewicz B, Rutkowski P, Małgorzewicz S, Rutkowski B,


Tylicki L, Debska-Slizien AM, Lizakowski S, Przybylska M, Heleniak Z, Renke M, Chamienia AL, Biedunkiewicz B, Rutkowski P, Małgorzewicz S, Rutkowski B, (click to view)

Tylicki L, Debska-Slizien AM, Lizakowski S, Przybylska M, Heleniak Z, Renke M, Chamienia AL, Biedunkiewicz B, Rutkowski P, Małgorzewicz S, Rutkowski B,

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Acta biochimica Polonica 2017 04 28() doi 10.18388/abp.2016_1297
Abstract
BACKGROUND
The renoprotective effects of the direct renin inhibitor, aliskiren, in renal transplant recipients have been supposed, but not finally proven. We performed an exploratory double-blind, losartan controlled, cross-over study to evaluate the influence of aliskiren, direct renin inhibitor, on albuminuria and other surrogate markers of kidney injury in patients after renal transplantation. The safety of this therapy was also evaluated.

METHOD
16 of 18 patients (12 M, 4 F), 48.3 ± 9.0 years, 57.7 ± 9.1 months after kidney transplantation, with hypertension and stable serum creatinine 1.4 ± 0.08 mg/dl without proteinuria, completed the protocol. Each patient underwent two 8-week treatment periods (one with 150 mg of aliskiren, and one with 50 mg of losartan) in random order, allowing an 8-week placebo washout between them.

RESULTS
There were no differences in albuminuria, transforming growth factor β-1 and 15-F2t-isoprostanes urine excretion between aliskiren and losartan. Creatinine serum level, eGFR, 24 h systolic and 24 h diastolic blood pressure were stable through the study. There were no differences in haemoglobin and potassium serum concentration between studied drugs.

CONCLUSION
Aliskiren decreases albuminuria in renal transplant recipients with clinically minimal side effects. The effect does not differ from that of losartan.

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