Spontaneous urticaria is a common allergic skin condition affecting individuals and may burden on health care expenditure. It can also be associated with remarkable morbidity. This study was done with the researchers to measure the effect of vitamin D supplementation in patients with a diagnosis of CSU. Quality of life and cytokine changes were evaluated as well.

The clinical trial was conducted on 20 patients with idiopathic chronic urticaria. Vitamin D was administered orally for 8 weeks and disease activity was measured pre-and post-treatment using USS and DLQI.

USS questionnaire showed that the severity of idiopathic urticaria after the intervention, which compared with the first day reached a significant 55% reduction. The DLQI quality of life questionnaire 2 months after treatment showed a 55% improvement.

There are some minor limitations of the study that might happen due to a lack of enrolled population in the investigation.

This study concluded through its findings Vitamin D can be used along with standard medical care and it’s a safe and cost-effective method for the treatment of chronic urticaria with deficiency of vitamin D.

Reference: https://clinicalmolecularallergy.biomedcentral.com/articles/10.1186/s12948-017-0078-z