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Amygdala Volume Differences in Autism Spectrum Disorder Are Related to Anxiety.

Amygdala Volume Differences in Autism Spectrum Disorder Are Related to Anxiety.
Author Information (click to view)

Herrington JD, Maddox BB, Kerns CM, Rump K, Worley JA, Bush JC, McVey AJ, Schultz RT, Miller JS,


Herrington JD, Maddox BB, Kerns CM, Rump K, Worley JA, Bush JC, McVey AJ, Schultz RT, Miller JS, (click to view)

Herrington JD, Maddox BB, Kerns CM, Rump K, Worley JA, Bush JC, McVey AJ, Schultz RT, Miller JS,

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Journal of autism and developmental disorders 2017 07 08() doi 10.1007/s10803-017-3206-1
Abstract

Recent studies suggest that longstanding findings of abnormal amygdala morphology in ASD may be related to symptoms of anxiety. To test this hypothesis, fifty-three children with ASD (mean age = 11.9) underwent structural MRI and were divided into subgroups to compare those with at least one anxiety disorder diagnosis (n = 29) to those without (n = 24) and to a typically developing control group (TDC; n = 37). Groups were matched on age and intellectual level. The ASD and anxiety group showed decreased right amygdala volume (controlled for total brain volume) relative to ASD without anxiety (p = .04) and TDCs (p = .068). Results suggest that youth with ASD and co-occurring anxiety have a distinct neurodevelopmental trajectory.

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