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An Alarmingly High Proportion of HIV-1 Isolates Carrying Mutations Corresponding to Resistance to Antiretroviral Drugs among HIV-Positive High-Risk Groups in Central Vietnam: a Substudy of the National Sentinel Survey.

An Alarmingly High Proportion of HIV-1 Isolates Carrying Mutations Corresponding to Resistance to Antiretroviral Drugs among HIV-Positive High-Risk Groups in Central Vietnam: a Substudy of the National Sentinel Survey.
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Do HT, Nguyen DT, Nguyen LAT, Do DH, Le HX, Trinh XMT, Ton HVN, Sawada I, Kitamura N, Le MN, Yoshihara K, Phan THT, Bui CT, Ariyoshi K, Yoshida LM,


Do HT, Nguyen DT, Nguyen LAT, Do DH, Le HX, Trinh XMT, Ton HVN, Sawada I, Kitamura N, Le MN, Yoshihara K, Phan THT, Bui CT, Ariyoshi K, Yoshida LM, (click to view)

Do HT, Nguyen DT, Nguyen LAT, Do DH, Le HX, Trinh XMT, Ton HVN, Sawada I, Kitamura N, Le MN, Yoshihara K, Phan THT, Bui CT, Ariyoshi K, Yoshida LM,

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Japanese journal of infectious diseases 2017 09 1170(6) 621-627 doi 10.7883/yoken.JJID.2016.512

Abstract

We studied the prevalence of HIV drug resistance among high-risk groups such as injecting drug users (IDUs), female sex workers (FSWs), and men having sex with men (MSM) in central Vietnam. We used HIV-positive blood samples from 2012-2013 sentinel surveillance surveys. Study subjects were screened for HIV infection by standardized screening assays, and the HIV-positive samples were further tested for HIV viral load and drug-resistance mutations (DRMs) by in-house assays. DRMs were identified using the Stanford University online sequence analysis tool. Their risk behaviors were also investigated. During the study period, 6,016 (high-risk) subjects were screened, and 97 tested positive for HIV infection (IDUs: n = 63, 3.0%; FSWs: n = 24, 0.9%; and MSM: n = 10, 1.0%). Ninety-two of the 97 samples (45 from 2012 and 47 from 2013) were available for further testing. HIV RNA was detected in 56 (60.9%) of the 92 samples, and drug resistance genotyping was successfully performed on 40 (71.4%) samples. All these isolates were subtype CRF01_AE, except for 1 (2.5%) IDU whose HIV belongs to subtype B. Thirteen individuals (32.5%) were carrying HIV with at least 1 DRM: 9 IDUs, 1 FSW, and 3 MSM. Thus, HIV seroprevalence among high-risk individuals in central Vietnam is low, but a high proportion of drug resistant HIV-1 isolates is observed in the high-risk group.

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