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Anal HPV 16 and 18 viral load: a comparison between HIV-negative and HIV-positive MSM and association with persistence.

Anal HPV 16 and 18 viral load: a comparison between HIV-negative and HIV-positive MSM and association with persistence.
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Marra E, King A, van Logchem E, van der Weele P, Mooij SH, Heijman T, M Meijer CJL, Verhagen DWM, van der Sande MAB, van der Loeff MFS,


Marra E, King A, van Logchem E, van der Weele P, Mooij SH, Heijman T, M Meijer CJL, Verhagen DWM, van der Sande MAB, van der Loeff MFS, (click to view)

Marra E, King A, van Logchem E, van der Weele P, Mooij SH, Heijman T, M Meijer CJL, Verhagen DWM, van der Sande MAB, van der Loeff MFS,

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Journal of medical virology 2017 07 12() doi 10.1002/jmv.24898

Abstract

Objective Does anal HPV viral load explain the difference in anal HPV persistence between HIV-negative and HIV-positive men who have sex with men (MSM)? Methods MSM ≥18 years were recruited in Amsterdam, the Netherlands, in 2010-2011. Anal self-swabs were collected every 6 months and genotyped (SPF10 -PCR-DEIA-LIPA25 -system). HPV16 and HPV18 load was determined with a type specific quantitative (q)PCR, and compared between HIV-negative and HIV-positive men using ranksum test. Persistence was defined as ≥3 positive samples for the same HPV-type. Determinants of persistent HPV16/18 infection and its association with HPV16/18 load were assessed with logistic regression. Results Of 777 recruited MSM, 54 and 22 HIV negative men were HPV16 and HPV18 positive at baseline, and 64 and 39 HIV-positive MSM. The geometric mean titer (GMT) of HPV16 was 19.6 (95%CI 10.1-38.0) and of HPV18 8.6 (95%CI 2.7-27.5) DNA copies/ human cell. HPV16 and HPV18 load did not differ significantly between HIV-negative and HIV-positive MSM (P = 0.7; P = 0.8, respectively). In multivariable analyses HPV16 load was an independent determinant of HPV16 persistence (OR 1.8, 95%CI 1.3-2.4). Conclusion No difference in anal HPV viral load was found between HIV-positive and HIV-negative MSM. HPV 16/18 viral load is an independent determinant of type-specific persistence. This article is protected by copyright. All rights reserved.

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