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Analysis of risk factors of rapid thyroidal radioiodine-131 turnover in Graves’ disease patients.

Analysis of risk factors of rapid thyroidal radioiodine-131 turnover in Graves’ disease patients.
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Zhang R, Tan J, Wang R, Zhang G, Jia Q, Meng Z, Zhang Y,


Zhang R, Tan J, Wang R, Zhang G, Jia Q, Meng Z, Zhang Y, (click to view)

Zhang R, Tan J, Wang R, Zhang G, Jia Q, Meng Z, Zhang Y,

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Scientific reports 2017 08 157(1) 8301 doi 10.1038/s41598-017-08475-z
Abstract

Rapid iodine-131((131)I) turnover in the thyroid gland is an important feature of Graves’ disease (GD) and also a strong predictor of radioiodine therapy failure. The aim of this study was to explore the predictors of rapid (131)I turnover. The clinical data on 2543 patients were retrospectively reviewed. Patients were divided into 2 groups depending on present or absent with rapid (131)I turnover defined as a 4-hour to 24-hour (131)I uptake ratio of ≥1. Overall, 590 cases (23.2%) had a rapid (131)I turnover. In the univariate analysis, gender, age, FT3/FT4 concentration, disease duration, with or without antithyroid drugs (ATD), time of ATD, thyroid weight and thyroid textures displayed significant differences. Cutoff values of age, FT3 and thyroid weight to predict rapid (131)I turnover were 38 years, 35 pmol/l and 56 g by receiver operating characteristic curves. Binary logistic regression analysis further revealed higher probability of rapid (131)I turnover in patients with thyroid weight ≥56 g (odds ratio [OR]:3.7, 95% confidence interval [CI]: 3.032-4.559), age <38 years (OR:2.3, 95%CI: 1.906-2.856), FT3 concentration ≥35 pmol/l (OR:7.6, 95%CI: 5.857-8.563) and females (OR:2.2, 95%CI: 1.757-2.791). In conclusion, larger goiters, younger age, higher FT3 concentration and females are independently associated with rapid (131)I turnover in GD patients.

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