Photo Credit: Dr Microbe
The following is a summary of “Clinical features, treatment and prognosis of patients with endogenous infectious endophthalmitis,” published in the July 2024 issue of Ophthalmology by Hu et al.
Researchers conducted a retrospective study examining changes over the past 5 years in the clinical characteristics, treatment approaches, and prognosis of endogenous infectious endophthalmitis (EIE).
They analyzed all articles on EIE published in the PubMed, Web of Science, and Embase databases from 2017 to 2021.
The result shows 128 patients and 147 eyes (46 left, 60 right), with a mean age at diagnosis of 51 ± 19 years. Predominant risk factors included diabetes and IV drug use. Klebsiella was the most prevalent pathogen (22%), with vitreous culture showing the highest positivity rate (2017 to 2021). Blurred vision was the most common symptom. Initial mean visual acuity (logMAR) was 2.84, accompanied by vitreal inflammation and opacity (63%), ocular pain (37%), and conjunctival congestion (36%). Intraocular antibiotics or vitrectomy reduced ocular inflammation. Visual prognosis remained poor, with a mean logMAR of 2.73, only 50% achieved finger count or better visual acuity. Over 5 years, diagnostic advances included broader microorganism culture methods such as PCR, sputum culture, and aqueous humor culture, enhancing positive culture rates and visual outcomes.
Investigators concluded that addressing pathogenic bacteria culture results, systemic diseases, and prompt diagnosis and treatment was crucial due to the poor prognosis of EIE.
Source: link.springer.com/article/10.1007/s10792-024-03208-4
