In this study, researchers aimed at evaluating the most recent research on exercise-induced anaphylaxis in order to give complete and up-to-date evidence and, perhaps, contribute to a better understanding of its pathophysiological causes and treatment techniques. From 1/2/2013 to 31/1/2014, the search strategy was carried out by scanning the primary electronic bibliographic database and hand-searching the important scientific papers in Allergy and Clinical Immunology. Among the discovered publications, 17 were chosen to be included in the systematic review. Five experimental trials, eight case reports, and four letters qualified as research. The overall quality of the evidence gathered was quite low. The search yielded no results for randomized controlled trials. The majority of the data came from reports conducted on tiny population samples or even individuals. Except for one paper on the prevention of exercise-induced anaphylaxis, all of the other studies focused on prevalence rates, causal triggers, and pathogenetic pathways. More intriguing discoveries included the role of the IL-4-C590T polymorphism at the beginning of wheat-dependent exercise-induced anaphylaxis, as well as the utility of the immune solid-phase allergen chip technology in the allergy screening of polysensitized athletes at risk of severe responses.
Reference:journals.lww.com/co-allergy/Abstract/2014/08000/Anaphylaxis_and_sport.11.aspx
