Thirteen examinations were remembered for this deliberate audit. Eleven partner examines including 339,400 cases and 436,851 controls were remembered for the primary meta-examination. ADT organization was related with a 21% expansion in dementia hazard (pooled HR = 1.21, 95% CI: 1.13–1.30, P < 0.001). Subgroup investigations dependent on ADT types demonstrated that luteinizing hormone-delivering hormone agonists (HR = 1.14, P < 0.001), two-sided orchiectomy (HR = 1.42, P < 0.001), oral antiandrogens (HR = 1.35, P = 0.138), and joined androgen barricade (HR = 1.22, P = 0.097) were decidedly identified with resulting danger of dementia, in spite of the fact that the distinctions were not measurably critical with oral antiandrogens and consolidated androgen bar. The current investigation demonstrated that ADT organization, regardless of with sorts of ADT, is related with the danger of dementia in patients with PCa. Future investigations are expected to decide if ADT causes dementia or is simply connected with expanded danger.

Reference link- https://www.nature.com/articles/s41391-020-00267-3