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Angiotensin-converting enzyme insertion/deletion gene polymorphism in Egyptian children with CAP: A case-control study.

Angiotensin-converting enzyme insertion/deletion gene polymorphism in Egyptian children with CAP: A case-control study.
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Abouzeid H, Alkholy UM, Abdou MA, Morsy SM, Abdelrahman HM, Sherif AM, Abdalmonem N, Hamed ME, Allah MAN, Al Morshedy S, Elashkar SSA, Noah MA, Hegab MS, Akeel NE, Hashem MIA, Gawish HH, Fattah LA,


Abouzeid H, Alkholy UM, Abdou MA, Morsy SM, Abdelrahman HM, Sherif AM, Abdalmonem N, Hamed ME, Allah MAN, Al Morshedy S, Elashkar SSA, Noah MA, Hegab MS, Akeel NE, Hashem MIA, Gawish HH, Fattah LA, (click to view)

Abouzeid H, Alkholy UM, Abdou MA, Morsy SM, Abdelrahman HM, Sherif AM, Abdalmonem N, Hamed ME, Allah MAN, Al Morshedy S, Elashkar SSA, Noah MA, Hegab MS, Akeel NE, Hashem MIA, Gawish HH, Fattah LA,

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Pediatric pulmonology 2017 10 13() doi 10.1002/ppul.23886
Abstract
BACKGROUND
Community-acquired pneumonia (CAP) is a major cause of childhood morbidity and mortality worldwide. The angiotensin-converting enzyme (ACE) gene is a potential candidate gene for CAP risk.

OBJECTIVES
In this study, we aimed to investigate whether the ACE insertion/deletion (I/D) polymorphism (rs4340) could be a genetic marker for CAP susceptibility in Egyptian children, and we also measured the serum ACE level to assess its relation to such polymorphism.

METHODS
This was a prospective case-control study included 300 patients with CAP, and 300 age, gender, and ethnicity matched healthy controls. The ACE I/D polymorphism (rs4340) at intron 16 was genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), while the serum ACE levels were measured by ELISA.

RESULTS
Compared to the controls subjects, the frequencies of the ACE DD genotype and D allele were overrepresented in patients with CAP (OR = 3.05; [95%CI: 2.14-4.35] for the DD genotype; P < 0.001) and (OR: 1.8; [95%CI: 1.42-2.29]; for the D allele; P < 0.01, respectively). Patients with the DD genotype had significantly higher mean serum ACE levels (45.6 ± 11.4 U/L) compared to those with ID genotype (36.5 ± 8.3 U/L) and II genotype (21.6 ± 5.7 U/L); P < 0.01, respectively. CONCLUSION
The ACE I/D polymorphism (rs4340) may contribute to the genetic susceptibility of CAP in Egyptian children. The ACE D allele and DD genotype were associated with higher serum ACE levels among studied CAP patients.

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