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Animal Models of Nonalcoholic Fatty Liver Disease-A Starter’s Guide.

Animal Models of Nonalcoholic Fatty Liver Disease-A Starter’s Guide.
Author Information (click to view)

Van Herck MA, Vonghia L, Francque SM,


Van Herck MA, Vonghia L, Francque SM, (click to view)

Van Herck MA, Vonghia L, Francque SM,

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Nutrients 2017 09 279(10) pii E1072
Abstract

Nonalcoholic fatty liver disease (NAFLD) constitutes a major health concern with the increasing incidence of obesity and diabetes in many Western countries, reaching a prevalence of up to 30% in the general population. Animal models have played a vital role in elucidating the pathophysiological mechanisms of NAFLD and continue to do so. A myriad of different models exists, each with its advantages and disadvantages. This review presents a brief overview of these models with a particular focus on the basic mechanisms and physical, biochemical and histological phenotype. Both nutritional and chemically induced, as well as genetic models are examined, including models combining different approaches.

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