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Anti-Müllerian hormone measurement for the diagnosis of polycystic ovary syndrome.

Anti-Müllerian hormone measurement for the diagnosis of polycystic ovary syndrome.
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Sathyapalan T, Al-Qaissi A, Kilpatrick ES, Dargham SR, Atkin SL,


Sathyapalan T, Al-Qaissi A, Kilpatrick ES, Dargham SR, Atkin SL, (click to view)

Sathyapalan T, Al-Qaissi A, Kilpatrick ES, Dargham SR, Atkin SL,

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Clinical endocrinology 2017 11 16() doi 10.1111/cen.13517
Abstract
OBJECTIVE
Anti-Müllerian hormone (AMH) is derived from the small antral follicles and an elevated level has been suggested to add value to the Rotterdam criteria for the diagnosis of PCOS in cases of diagnostic uncertainty. Therefore, the role of AMH in the classical phenotype of PCOS was defined within a Caucasian population.

DESIGN
This was a cross sectional study.

PATIENTS
65 women without PCOS and 110 women with PCOS fulfilling all 3 diagnostic Rotterdam criteria.

MEASUREMENTS
The main outcomes were the utility of serum AMH for the diagnosis of PCOS and its relationship to the metabolic parameters.

RESULTS
AMH was increased in PCOS compared to controls (p<0.001) Areas under the receiver operator curve showed AMH to be predictive of PCOS (0.76) using a cut off AMH of 46pmol/l, derived from the 95(th) percentile of the controls gave a 41% sensitivity and 86% specificity; an AMH cut off of 35pmol/l gave a 55% sensitivity and 79% specificity. Age and BMI adjusted multiple logistic regression showed that AMH was more predictive of PCOS independently of either serum testosterone (T) (OR = 4.04; 95% CI 1.42-11.11; p=0.007) or free androgen index (FAI) (OR = 3.90; 95% CI 1.40-10.83; p=0.009). CONCLUSION
Whilst an elevated AMH has poor sensitivity, it is four fold more likely to be associated with a diagnosis of PCOS, and supplementary to biochemical parameters will make a positive diagnosis of PCOS in 22% of patients when neither serum testosterone or FAI are elevated. This article is protected by copyright. All rights reserved.

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