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Antiviral Activity of Tenofovir Alafenamide Against HIV-1 Subtypes and Emergence of K65R.

Antiviral Activity of Tenofovir Alafenamide Against HIV-1 Subtypes and Emergence of K65R.
Author Information (click to view)

Cox S, Margot N, Miller M, Callebaut C,


Cox S, Margot N, Miller M, Callebaut C, (click to view)

Cox S, Margot N, Miller M, Callebaut C,

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AIDS research and human retroviruses 2018 04 10() doi 10.1089/AID.2017.0248

Abstract

Differences in emergence of HIV resistance between subtypes B and C in vitro and potential implications on tenofovir alafenamide efficacy in vivo were evaluated. Dose escalation resistance selections showed K65R emerging earlier for subtype C viruses in vitro, as previously reported. Viral breakthrough experiments at therapeutic drug concentrations, however, showed no difference in time to breakthrough between these subtypes. Finally, clinical trial data found no evidence of greater K65R emergence in patients harboring subtype C HIV.

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