Here are what the editors at HealthDay consider to be the most important developments in Pathology for April 2020. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Symptomatic Health Care Staff in U.K. Screened for COVID-19

THURSDAY, April 30, 2020 (HealthDay News) — Screening symptomatic health care workers for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is feasible during the pandemic, according to a research letter published online April 22 in The Lancet.

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David Shulkin, M.D., on COVID-19 Financial Consequences for Health Care System

MONDAY, April 27, 2020 (HealthDay News) — Health care organizations are facing hard financial decisions amid the COVID-19 pandemic, but an end is in sight as some are beginning to slowly open back up around the country, according to David Shulkin, M.D. Shulkin, who served as ninth secretary for Veterans Affairs and is former president and CEO of Beth Israel Medical Center in New York, spoke with HealthDay during a live stream on the HealthDay YouTube channel and live blog.

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KIMT3 Article

Multicancer Blood Test, PET-CT Combo Feasible for Cancer Screen

WEDNESDAY, April 29, 2020 (HealthDay News) — Multicancer blood testing combined with positron emission tomography-computed tomography (PET-CT) imaging can detect cancers, according to a study published online April 28 in Science to coincide with the virtual annual meeting of the American Association for Cancer Research.

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Thromboembolic Complications in COVID-19 Discussed

WEDNESDAY, April 29, 2020 (HealthDay News) — Prevention, diagnosis, and therapeutic management of thromboembolic complications in COVID-19 are discussed in a report published online April 23 in Radiology.

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WHO: No Evidence COVID-19 Survivors Cannot Be Reinfected

MONDAY, April 27, 2020 (HealthDay News) — There is “no evidence” that people who have recovered from COVID-19 cannot be reinfected with the severe acute respiratory syndrome coronavirus 2, according to the World Health Organization.

CBS News Article
CNN Article
More Information: CDC

Direct Medical Costs of COVID-19 Infection Are Considerable

MONDAY, April 27, 2020 (HealthDay News) — A single symptomatic COVID-19 infection results in direct medical costs of $3,045 in the United States, according to a study published online April 23 in Health Affairs.

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SARS-CoV-2 Not Detected in Semen After COVID-19 Recovery

MONDAY, April 27, 2020 (HealthDay News) — Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is not detected in the semen of patients one month after COVID-19 diagnosis, according to a study published online April 17 in Fertility and Sterility.

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Former Footballers Report Chronic Traumatic Encephalopathy Symptoms

MONDAY, April 27, 2020 (HealthDay News) — A number of former American-style football (ASF) players report clinician-diagnosed chronic traumatic encephalopathy (CTE), and they have significantly more comorbidities and cognitive impairment symptoms, according to a study published online April 13 in the Annals of Neurology.

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Surprise Billing Found for Visits to Ambulatory Surgery Centers

MONDAY, April 27, 2020 (HealthDay News) — After insurer payment, potential surprise bills to patients for out-of-network providers occur in 8 percent of episodes at in-network ambulatory surgery centers (ASCs), according to a report published online April 15 in Health Affairs.

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Physician’s Briefing Weekly Coronavirus Roundup

Here is what the editors at Physician’s Briefing chose as the most important COVID-19 developments for you and your practice for the week of April 20 to 24, 2020. This roundup includes the latest research news from journal studies and other trusted sources that is most likely to affect clinical practice.

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Premature Posting of Remdesivir Findings Were ‘Inconclusive’

FRIDAY, April 24, 2020 (HealthDay News) — Inconclusive findings from a study investigating the antiviral drug remdesivir as a treatment for COVID-19 were posted to the World Health Organization website “prematurely,” drug maker Gilead Sciences said Thursday.

CNN Article

SARS-CoV-2 Stays in Respiratory Samples Longer in Severely Ill

FRIDAY, April 24, 2020 (HealthDay News) — The median duration of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA is significantly longer in the respiratory samples of patients with severe versus mild disease, according to a study published online April 21 in The BMJ.

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Infection Rate Up Prior to Detection of Malignant Cancer

FRIDAY, April 24, 2020 (HealthDay News) — The rate of infection with influenza, gastroenteritis, hepatitis, and pneumonia is increased before detection of malignant cancer, according to a study published online April 17 in Cancer Immunology Research.

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‘Health Force’ to Combat Pandemic Proposed by U.S. Senators

THURSDAY, April 23, 2020 (HealthDay News) — A bill to create a “Health Force” to help combat the U.S. COVID-19 outbreak has been announced by two Democratic senators.

NBC News Article

SARS-CoV-2 Can Spread Rapidly in Homeless Shelters

THURSDAY, April 23, 2020 (HealthDay News) — Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can spread rapidly in homeless shelters, according to two studies published in the April 22 early-release issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.

Abstract/Full Text – Tobolowsky
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Mild, No Symptoms Seen for Most Children With SARS-CoV-2 Infection

THURSDAY, April 23, 2020 (HealthDay News) — Most children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have mild respiratory symptoms or are asymptomatic, according to a review published online April 22 in JAMA Pediatrics.

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AAD Establishes Registry for Skin Manifestations of COVID-19

THURSDAY, April 23, 2020 (HealthDay News) — A registry has been created for reporting skin manifestations of COVID-19 following reports of patients presenting with skin conditions, including findings outlined in a letter to the editor published online March 26 in the Journal of the European Academy of Dermatology and Venereology.

Registry
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Rapid COVID-19 Test Can Produce False Negatives

WEDNESDAY, April 22, 2020 (HealthDay News) — A widely used rapid COVID-19 test can produce false negatives if a certain solution is used to move or store patients’ samples, the test’s maker said.

CNN Article

Clinical, Genetic, Biomarker Model IDs Risk for Pancreatic Cancer

WEDNESDAY, April 22, 2020 (HealthDay News) — A model that includes data on clinical and genetic factors and circulating biomarkers may improve risk discrimination for pancreatic cancer, according to a study published online April 22 in Cancer Epidemiology, Biomarkers & Prevention.

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Obesity Ups Risk for COVID-19 Severity

WEDNESDAY, April 22, 2020 (HealthDay News) — There is a high frequency of obesity among patients admitted to intensive care for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), according to a study published online April 9 in Obesity.

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Alone, Low Vitamin D Does Not Cause Osteoporotic Fractures

WEDNESDAY, April 22, 2020 (HealthDay News) — While low blood levels of vitamin D are associated with osteoporotic fractures, the link is not causative, according to the results of an analysis published online April 7 in Clinical Chemistry.

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COVID-19 Tied to Unique Nasal Symptoms

TUESDAY, April 21, 2020 (HealthDay News) — COVID-19 is not associated with the symptoms typically associated with a viral cold or allergies, such as nasal blockage or mucus production, according to a review published online April 10 in Laryngoscope Investigative Otolaryngology.

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LA County COVID-19 Infections Far Exceed Number of Confirmed Cases

TUESDAY, April 21, 2020 (HealthDay News) — An early analysis of antibody testing from Los Angeles County reveals a COVID-19 infection rate that is up to 55 times the number of confirmed COVID-19 cases.

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FDA Authorizes COVID-19 Test That Uses Samples Collected at Home

TUESDAY, April 21, 2020 (HealthDay News) — The U.S. Food and Drug Administration has approved emergency use of the first COVID-19 test that enables patients to take samples at home.

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Expanding Symptom Screening Criteria Can Up COVID-19 Detection

TUESDAY, April 21, 2020 (HealthDay News) — Expanding COVID-19 symptom screening criteria to include myalgias and chills could identify more health care personnel (HCP) with the illness, according to a research letter published online April 17 in the Journal of the American Medical Association.

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176,190 U.S. Children Estimated to Have SARS-CoV-2 by April 6, 2020

TUESDAY, April 21, 2020 (HealthDay News) — About 176,190 children nationwide were estimated to be infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by April 6, 2020, according to a study published online April 16 in the Journal of Public Health Management & Practice.

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Coinfection With SARS-CoV-2, Other Respiratory Pathogens ID’d

TUESDAY, April 21, 2020 (HealthDay News) — About 20 percent of specimens positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are positive for other respiratory pathogens, according to a research letter published online April 15 in the Journal of the American Medical Association.

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Bundled Rapid HIV/Hep C Testing May Improve Infection Awareness

TUESDAY, April 21, 2020 (HealthDay News) — For people with substance use disorders, combining HIV and hepatitis C virus (HCV) testing and providing immediate test results may increase the number of people who are aware of their infection status, according to a study published in the May issue of Medical Care.

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Public Health Measures Cut COVID-19 Transmission in Hong Kong

MONDAY, April 20, 2020 (HealthDay News) — Public health measures implemented to suppress local transmission of COVID-19 in Hong Kong were associated with reduced transmission of COVID-19 and influenza, according to a study published online April 17 in The Lancet Public Health.

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Lab Protocol Failures Led to Ineffective COVID-19 Tests From CDC

MONDAY, April 20, 2020 (HealthDay News) — The first COVID-19 tests in the United States were ineffective due to poor laboratory practices at the U.S. Centers for Disease Control and Prevention, the U.S. Food and Drug Administration said.

The New York Times Article

Family History-Based Early Screen Could ID More Young-Onset CRC

MONDAY, April 20, 2020 (HealthDay News) — About one in four cases of colorectal cancer (CRC) in patients aged 40 to 49 years meet family history-based criteria for early screening, according to a study published online April 20 in Cancer.

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Hypertension in Pregnancy Ups Risk for Mental Disorder in Child

MONDAY, April 20, 2020 (HealthDay News) — Maternal hypertensive pregnancy disorders are associated with increased risk in offspring for any childhood mental disorder, according to a study published online April 20 in Hypertension.

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Benefit of Social Distancing Outweighs Economic Impact

MONDAY, April 20, 2020 (HealthDay News) — The economic benefits of lives saved through social distancing substantially outweigh the value of the projected losses to the U.S. economy, according to a study to be published in a forthcoming issue of the Journal of Benefit-Cost Analysis.

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Diabetes Increases Risk for Poorer Prognosis in COVID-19

MONDAY, April 20, 2020 (HealthDay News) — Diabetes may contribute to more severe symptoms, rapid progression, and poorer prognosis in patients infected with COVID-19, according to a study published online March 31 in Diabetes Metabolism Research and Reviews.

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Physician’s Briefing Weekly Coronavirus Roundup

Here is what the editors at Physician’s Briefing chose as the most important COVID-19 developments for you and your practice for the week of April 13 to 17, 2020. This roundup includes the latest research news from journal studies and other trusted sources that is most likely to affect clinical practice.

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CDC Looks at Transmission of COVID-19 to Health Care Workers

FRIDAY, April 17, 2020 (HealthDay News) — Transmission of coronavirus disease 2019 (COVID-19) to health care personnel (HCP) is explored in two studies published in the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.

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Incidence of SARS-CoV-2 Infection Stable in Iceland

FRIDAY, April 17, 2020 (HealthDay News) — In Iceland, the incidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was stable through 20 days of screening, according to a study published online April 14 in the New England Journal of Medicine.

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IDSA Issues Rapid Guidelines for Treatment of COVID-19

FRIDAY, April 17, 2020 (HealthDay News) — In rapid guidelines issued by the Infectious Diseases Society of America (IDSA), recommendations are presented for the treatment and management of coronavirus disease 2019 (COVID-19).

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CDC: 2009 to 2017 Saw Increase in Oral Cavity, Pharynx Cancers

FRIDAY, April 17, 2020 (HealthDay News) — From 2007 to 2016, the incidence of cancers of the oral cavity and pharynx combined increased, according to research published in the April 17 issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.

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Risk for Severe COVID-19 May Be Up in People With COPD, Smokers

FRIDAY, April 17, 2020 (HealthDay News) — Active cigarette smokers and individuals with chronic obstructive pulmonary disease (COPD) have up-regulation of angiotensin converting enzyme II (ACE-2) expression in the lower airways, which could explain the increased risk for severe COVID-19 in these subpopulations, according to a study published online April 8 in the European Respiratory Journal.

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FDA Urges COVID-19 Survivors to Donate Plasma

THURSDAY, April 16, 2020 (HealthDay News) — The U.S. Food and Drug Administration is asking Americans who have recovered from coronavirus disease 2019 (COVID-19) to donate their blood plasma to help fight the pandemic.

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CRISPR-Based Test Can Diagnose COVID-19 in Under 60 Minutes

THURSDAY, April 16, 2020 (HealthDay News) — Researchers say they have developed a low-cost swab test that can diagnose coronavirus disease 2019 (COVID-19) infections in about 45 minutes.

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Sharp Drop in Demand Seen for COVID-19 Tests at Private Labs

THURSDAY, April 16, 2020 (HealthDay News) — There has been such a drop in demand for coronavirus disease 2019 (COVID-19) tests at private labs in the United States that they have “considerable” unused capacity and can test more patients with less severe symptoms, the American Clinical Laboratory Association (ACLA) says.

NBC News Article

Recurrent Winter Outbreaks of SARS-CoV-2 Projected

THURSDAY, April 16, 2020 (HealthDay News) — Recurrent winter outbreaks of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) are projected to occur after the initial pandemic wave, according to a study published online April 14 in Science.

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Regardless of Genetics, Obesity Ups Risk for Type 2 Diabetes

THURSDAY, April 16, 2020 (HealthDay News) — Having normal body weight is crucial in the prevention of type 2 diabetes, regardless of genetic predisposition, according to a study published online April 15 in Diabetologia.

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Prevalence of Autoimmunity May Be on the Rise

THURSDAY, April 16, 2020 (HealthDay News) — The prevalence of antinuclear antibodies (ANA) in the United States has increased considerably between 1988 and 2012, according to a study published online April 7 in Arthritis & Rheumatology.

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Obesity Is Risk Factor for COVID-19 Hospital Admission in <60s

WEDNESDAY, April 15, 2020 (HealthDay News) — Obesity is associated with admission to the hospital for coronavirus disease 2019 (COVID-19) patients, according to a study published online April 9 in Clinical Infectious Diseases and a study not yet peer reviewed and posted on medRxiv.org.

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CDC: Five Causes Account for ~90 Percent of Fetal Deaths

WEDNESDAY, April 15, 2020 (HealthDay News) — Five causes of death accounted for 89.5 percent of fetal deaths reported during 2015 to 2017, according to a report published April 15 in the U.S. Centers for Disease Control and Prevention National Vital Statistics Report.

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Prognostic Score Predicts Time to First Treatment in Leukemia

WEDNESDAY, April 15, 2020 (HealthDay News) — An international prognostic score (IPS-E) can predict time to first treatment (TTFT) for chronic lymphocytic leukemia (CLL) patients with early, asymptomatic disease, according to a study published online April 8 in Blood.

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SARS-CoV-2 Contamination of Air, Surfaces Examined in ICU, Wards

WEDNESDAY, April 15, 2020 (HealthDay News) — Considerable severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) contamination of air and object surfaces is reported in intensive care units (ICUs) and general coronavirus disease 2019 (COVID-19) wards (GW), according to a study published online April 10 in Emerging Infectious Diseases, a publication of the U.S. Centers for Disease Control and Prevention.

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Public Health Interventions Improved COVID-19 Control in Wuhan

WEDNESDAY, April 15, 2020 (HealthDay News) — Multifaceted public health interventions improved control of the coronavirus disease 2019 (COVID-19) outbreak in Wuhan, China, according to a study published online April 10 in the Journal of the American Medical Association.

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Editorial

Common Coronaviruses Are Highly Seasonal

WEDNESDAY, April 15, 2020 (HealthDay News) — Common coronaviruses circulate seasonally, according to a study published online April 4 in the Journal of Infectious Diseases.

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Smell, Taste Impairment Linked to COVID-19 Positivity

TUESDAY, April 14, 2020 (HealthDay News) — Smell and taste impairment are strongly associated with coronavirus disease 2019 (COVID-19) positivity, according to a study published online April 12 in the International Forum of Allergy & Rhinology.

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Review: Quarantine Effective for Reducing Infection, Death

TUESDAY, April 14, 2020 (HealthDay News) — Quarantine is effective for reducing the number of people infected and deaths from coronavirus disease 2019 (COVID-19), according to a review published online April 8 in the Cochrane Database of Systematic Reviews.

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CDC: Public Policy Measures Important for Social Distancing

TUESDAY, April 14, 2020 (HealthDay News) — Community mobility in four metropolitan areas decreased with the introduction of public policy measures supporting social distancing, which could help slow the spread of coronavirus disease 2019 (COVID-19), according to research published in the April 13 early-release issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.

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U.S. Government Says COVID-19 Antibody Tests Must Be Free

TUESDAY, April 14, 2020 (HealthDay News) — Health insurers and Medicaid must provide free coverage for tests to detect coronavirus 2019 (COVID-19) antibodies in people who have been infected, the federal government says.

CBS News Article
Johns Hopkins University

First Saliva Test for COVID-19 Approved by FDA

TUESDAY, April 14, 2020 (HealthDay News) — The first saliva test for coronavirus 2019 (COVID-19) was approved Monday by the U.S. Food and Drug Administration.

AP News Article
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KL-VSHET+ Genotype Linked to Reduced Alzheimer Disease Risk

TUESDAY, April 14, 2020 (HealthDay News) — Klotho-VS heterozygosity (KL-VSHET+ status) is associated with a reduced risk for Alzheimer disease (AD) and β-amyloid (Aβ) burden in cognitively normal individuals aged older than 60 years who carry apolipoprotein e4 (APOE4), according to research published online April 13 in JAMA Neurology.

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Hep C Screening Recommended for Adults, Pregnant Women

TUESDAY, April 14, 2020 (HealthDay News) — Hepatitis C screening is recommended for all adults and for all pregnant women, except where the prevalence is below 0.1 percent; meanwhile, the annual rate of reported acute hepatitis C cases increased to 1.2 per 100,000 population in 2018, according to recommendations and a report published in the April 10 issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.

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Being Born Via C-Section May Up Risk for T2DM in Adulthood

TUESDAY, April 14, 2020 (HealthDay News) — Women born by cesarean delivery may have a higher risk for being obese and developing type 2 diabetes during adult life than women born by vaginal delivery, according to a study published online April 13 in JAMA Network Open.

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Medical Masks May Be Sufficient During COVID-19 Routine Care

TUESDAY, April 14, 2020 (HealthDay News) — Use of medical masks, such as surgical or procedural masks, does not increase the risk for viral infection or respiratory illness, and their use may serve as a protective measure in instances of N95 respirator shortages, according to the results of a meta-analysis published online April 4 in Influenza and Other Respiratory Viruses.

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COVID-19 RNA Detectable in Patient Fecal Matter

TUESDAY, April 14, 2020 (HealthDay News) — The presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA is detectable in the feces of COVID-19 patients and remains even after negative conversion in pharyngeal swabs, according to a study published online April 3 in the Journal of Medical Virology.

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First Wave of COVID-19 Abated With Control Measures in China

TUESDAY, April 14, 2020 (HealthDay News) — Interventions implemented in China interrupted coronavirus disease 2019 (COVID-19) transmission in all areas outside of Hubei, and low transmissibility can be maintained by monitoring the instantaneous effective reproduction number (Rt), according to a study published online April 8 in The Lancet.

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Editorial

COVID-19 Antibody Tests Underway in California

MONDAY, April 13, 2020 (HealthDay News) — Large-scale studies of tests to check for antibodies to coronavirus 2019 (COVID-19) are underway in California. The findings from this research could help the United States develop strategies to get people back to work and restart the economy.

NBC News Article

Chloroquine COVID-19 Trial Stopped After Patient Deaths

MONDAY, April 13, 2020 (HealthDay News) — A study of chloroquine in coronavirus 2019 (COVID-19) patients was halted due to potentially deadly side effects.

The New York Times Article

CDC Report Details Geographic Variation in U.S. COVID-19 Cases, Deaths

MONDAY, April 13, 2020 (HealthDay News) — There is variation in the cumulative incidence of coronavirus disease 2019 (COVID-19) across jurisdictions in the United States, according to research published in the April 10 early-release issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.

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Recommendations Issued for Use of Imaging in Adults With COVID-19

MONDAY, April 13, 2020 (HealthDay News) — In a multinational consensus statement from the Fleischner Society, published online April 7 in Radiology, recommendations are presented for use of imaging in patients with coronavirus disease 2019 (COVID-19).

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Guidance Issued for Infants Born to Mothers With COVID-19

MONDAY, April 13, 2020 (HealthDay News) — In an initial guidance document issued by the American Academy of Pediatrics, recommendations are presented for the management of infants born to mothers with suspected or confirmed coronavirus disease 2019 (COVID-19).

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Physician’s Briefing Weekly Coronavirus Roundup

Here is what the editors at Physician’s Briefing chose as the most important COVID-19 developments for you and your practice for the week of April 6 to 10, 2020. This roundup includes the latest research news from journal studies and other trusted sources that is most likely to affect clinical practice.

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Contact Tracing ID’d Large Multifamily COVID-19 Cluster in Chicago

FRIDAY, April 10, 2020 (HealthDay News) — One index patient with COVID-19 and only mild symptoms attended two family gatherings and likely triggered a chain of transmission that included 15 other confirmed and probable cases with three deaths, according to research published in the April 8 early-release issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.

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Temperature, UV Radiation Not Linked to Incidence of COVID-19

FRIDAY, April 10, 2020 (HealthDay News) — Ambient temperature and ultraviolet (UV) radiation are not associated with the cumulative incidence rate or basic reproduction number (R0) of coronavirus disease 2019 (COVID-19), according to a research letter published online April 8 in the European Respiratory Journal.

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FDA Approves New Way to Decontaminate N95 Face Masks

FRIDAY, April 10, 2020 (HealthDay News) — The second emergency use authorization to decontaminate N95 face masks and equivalents for reuse by hospital health care workers has been issued by the U.S. Food and Drug Administration.

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Neurologic Effects Seen in a Third of Hospitalized COVID-19 Patients

FRIDAY, April 10, 2020 (HealthDay News) — Neurologic manifestations are common among hospitalized patients with COVID-19, according to a study published online April 10 in JAMA Neurology.

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Face Masks Offer Slight Protective Effect From Flu-Like Illness

FRIDAY, April 10, 2020 (HealthDay News) — Wearing face masks could be slightly protective against primary infection with influenza-like illness from casual community contact, according to a review that has not yet been peer reviewed and was posted online April 6 at medRxiv.org.

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Current Models for COVID-19 Diagnosis, Prognosis Unreliable

FRIDAY, April 10, 2020 (HealthDay News) — Novel coronavirus (COVID-19)-related models that are published in the literature are poorly reported and at high risk for bias, raising concern that their predictions could be unreliable when applied in daily practice, according to a review published online April 7 in The BMJ.

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Clinical Trial Underway to Test Nitric Oxide in COVID-19 Patients

THURSDAY, April 9, 2020 (HealthDay News) — Doctors at the University of Alabama at Birmingham (UAB) are enrolling patients in an international clinical trial to find out if inhaled nitric oxide benefits those with novel coronavirus (COVID-19) who have severely damaged lungs.

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Another COVID-19 Vaccine Trial Begins in the United States

THURSDAY, April 9, 2020 (HealthDay News) — Another clinical trial of an experimental vaccine for the novel coronavirus 2019 (COVID-19) has been launched by U.S. researchers.

AP News Article

FDA Warns of False Claims That Chlorine Dioxide Can Treat COVID-19

THURSDAY, April 9, 2020 (HealthDay News) — A warning letter has been sent to a company marketing fraudulent and dangerous chlorine dioxide products for the prevention and treatment of the novel coronavirus (COVID-19), the U.S. Food and Drug Administration says.

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COVID-19 Came to New York City From Europe, Not Asia

THURSDAY, April 9, 2020 (HealthDay News) — The novel coronavirus (COVID-19) has been circulating in New York City for longer than previously believed and most cases can be traced back to Europe, new research reveals.

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Johns Hopkins University

NIH Launches Clinical Trial of Hydroxychloroquine for COVID-19

THURSDAY, April 9, 2020 (HealthDay News) — A clinical trial to assess the antimalarial drug hydroxychloroquine as a treatment for adults with the novel coronavirus (COVID-19) is now underway, the U.S. National Institutes of Health said Thursday.

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Older Adults, Men, Preexisting Conditions Tied to COVID-19 Death

THURSDAY, April 9, 2020 (HealthDay News) — Researchers have identified the most common clinical characteristics among 109 patients out of 1,017 with confirmed novel coronavirus (COVID-19) pneumonia who died of COVID-19-related pneumonia in Wuhan, China; their findings were published online April 7 in the Annals of the American Thoracic Society.

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Air Pollution May Hasten Cognitive Decline in Older Adults

THURSDAY, April 8, 2020 (HealthDay News) — Exposure to air pollution may have adverse effects on cognitive aging and brain health in older adults, according to a study published online April 8 in Neurology.

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Convalescent Plasma Treatment Promising in Severe COVID-19

THURSDAY, April 9, 2020 (HealthDay News) — One dose of convalescent plasma (CP) therapy is well tolerated and can potentially improve clinical symptoms in severe cases with coronavirus disease 2019 (COVID-19), according to a study published online April 6 in the Proceedings of the National Academy of Sciences.

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CDC Removes Prescribing Guidelines for Antimalarial Drugs

WEDNESDAY, April 8, 2020 (HealthDay News) — Guidelines for doctors on how to prescribe two antimalarial drugs that some believe may treat the novel coronavirus (COVID-19) are no longer available on the U.S. Centers for Disease Control and Prevention website.

CNN Article
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Johns Hopkins University

COVID-19 Killing Two Times More Men Than Women in NYC

WEDNESDAY, April 8, 2020 (HealthDay News) — The novel coronavirus (COVID-19) death rate in New York City is two times higher among men than among women, and men also have higher rates of infection and hospitalization, new data show.

The New York Times Article
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Surgical, Cotton Masks Not Effective for Filtering SARS-CoV-2

WEDNESDAY, April 8, 2020 (HealthDay News) — For patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), neither surgical nor cotton masks effectively filter SARS-CoV-2 during coughs, according to a research letter published online April 6 in the Annals of Internal Medicine.

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Celiac Disease May Slightly Increase Mortality Risk

WEDNESDAY, April 8, 2020 (HealthDay News) — Patients with celiac disease have a small but statistically significantly increased mortality risk compared with controls, according to a study published in the April 7 issue of the Journal of the American Medical Association.

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Some Multidrug-Resistant Bacterial Infections Down in U.S.

WEDNESDAY, April 8, 2020 (HealthDay News) — From 2012 to 2017, there were decreases in the incidence of some multidrug-resistant (MDR) bacterial infections in hospitalized patients in the United States, according to a study published in the April 2 issue of the New England Journal of Medicine.

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Side Effects Seen With Use of Chloroquine Against COVID-19

TUESDAY, April 7, 2020 (HealthDay News) — The use of the antimalarial drug chloroquine to treat COVID-19 patients has been halted at several Swedish hospitals due to reported side effects such as cramps and loss of peripheral vision. Sahlgrenska University Hospital is one of those facilities. It stopped the use of chloroquine in the treatment of COVID-19 about two weeks ago.

Newsweek Article
Johns Hopkins University

USPSTF Against Bacterial Vaginosis Screening to Prevent Preterm Delivery

TUESDAY, April 7, 2020 (HealthDay News) — The U.S. Preventive Services Task Force (USPSTF) recommends against screening for bacterial vaginosis in pregnant women not at increased preterm delivery risk, and more research is needed for those at increased risk. These findings form the basis of a final recommendation statement published in the April 7 issue of the Journal of the American Medical Association.

Evidence Report
Final Recommendation Statement
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Most COVID-19 Fatalities Are Men Over 50 With Chronic Disease

TUESDAY, April 7, 2020 (HealthDay News) — Most fatal cases of coronavirus disease 2019 (COVID-19) occur in men aged older than 50 years with noncommunicable chronic diseases, according to a study published online April 3 in the American Journal of Respiratory and Critical Care Medicine.

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Recommendations Issued for GI Procedures During COVID-19

TUESDAY, April 7, 2020 (HealthDay News) — In a document issued by the American Gastroenterological Association, published online April 1 in Gastroenterology, recommendations are presented for gastrointestinal (GI) procedures during the coronavirus disease 2019 (COVID-19) pandemic.

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School Closures Could Further Complicate COVID-19 Effort

TUESDAY, April 7, 2020 (HealthDay News) — Potential contagion prevention from school closures needs to be weighed against the potential loss of health care workers due to child care obligations during the coronavirus disease 2019 (COVID-19) pandemic, according to a study published online April 3 in The Lancet Public Health.

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Genetic Testing Does Not Enhance Heart Disease Risk Prediction

TUESDAY, April 7, 2020 (HealthDay News) — Genetic testing is not better at predicting coronary heart disease risk compared with conventional risk factors, according to a study published in a recent issue of the Journal of the American Medical Association.

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FDA Authorizes Use of Chinese-Approved Masks in United States

MONDAY, April 6, 2020 (HealthDay News) — Emergency use authorization of protective masks that do not meet American standards has been announced by the U.S. Food and Drug Administration.

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More Information: CDC
Johns Hopkins University

Majority of Physicians Report Serious Concerns About COVID-19

MONDAY, April 6, 2020 (HealthDay News) — According to a national survey conducted by Harvard Medical School, the RAND Corporation, and Doximity, practicing physicians currently report substantial concerns about supplies, the government response, and availability of testing amid the COVID-19 pandemic.

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Sentinel Surveillance Can Help Monitor Epidemiology of COVID-19

MONDAY, April 6, 2020 (HealthDay News) — Rapid sentinel surveillance can help monitor the epidemiology of coronavirus disease 2019 (COVID-19), according to research published in the April 3 early-release issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.

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Extracorporeal Membrane Oxygenation Might Aid in Severe COVID-19

MONDAY, April 6, 2020 (HealthDay News) — Extracorporeal membrane oxygenation (ECMO) support might improve clinical outcomes in severe cases of coronavirus disease 2019 (COVID-19) that cannot be adequately managed with mechanical ventilation alone, according to research published online March 30 in the ASAIO Journal.

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Brain Changes From Multiple Sclerosis May Occur in Preteens

MONDAY, April 6, 2020 (HealthDay News) — Greater genetic predisposition for multiple sclerosis (MS) is associated with altered brain white matter development at an early age, according to a study published online March 12 in the Annals of Neurology.

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Physician’s Briefing Weekly Coronavirus Roundup

Here is what the editors at Physician’s Briefing chose as the most important COVID-19 developments for you and your practice for the week of March 30 to April 3, 2020. This roundup includes the latest research news from journal studies and other trusted sources that is most likely to affect clinical practice.

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Test Vaccine Elicits Strong Ab Response to SARS-CoV-2 in Mice

FRIDAY, April 3, 2020 (HealthDay News) — Microneedle array (MNA) delivery of trimeric coronavirus spike (S) protein subunit vaccines seems promising for immunization against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, according to research published online April 2 in EBioMedicine.

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Enrollment Begins in NIH-Sponsored Trial of Remdesivir for COVID-19 Patients

FRIDAY, April 3, 2020 (HealthDay News) — A number of institutions this week announced their participation in an international clinical drug trial evaluating the safety and efficacy of remdesivir in hospitalized patients with the novel coronavirus 2019 (COVID-19).

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Model Projects COVID-19 Deaths in Italy Through Mid-April

FRIDAY, April 3, 2020 (HealthDay News) — Modeling suggests that in Italy, the number of coronavirus disease 2019 (COVID-19) intensive care unit (ICU) patients will continue increasing into April, according to a report published April 1 by the European Society of Anaesthesiology.

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Gastrointestinal Symptoms Common in COVID-19 Patients

FRIDAY, April 3, 2020 (HealthDay News) — Gastrointestinal symptoms are common in patients with coronavirus disease 2019 (COVID-19), with increased prevalence seen in the later stages of the epidemic in China, according to a review published online March 29 in Alimentary Pharmacology & Therapeutics.

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Test for COVID-19 Antibodies Approved by FDA

FRIDAY, April 3, 2020 (HealthDay News) — The first COVID-19 virus antibody test for use in the United States has been approved by the Food and Drug Administration.

The New York Times Article
More Information: FDA
Johns Hopkins University

Unemployed Workers Less Likely to Be Uninsured Post-ACA

THURSDAY, April 2, 2020 (HealthDay News) — Following implementation of the Affordable Care Act (ACA), unemployed workers were less likely to be uninsured, and uninsurance rates decreased more in states with Medicaid expansion, according to a report from the Urban Institute and the Robert Wood Johnson Foundation.

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Transmission Control Measures Tied to Delay in COVID-19 Growth

THURSDAY, April 2, 2020 (HealthDay News) — Transmission control measures implemented in Wuhan were associated with a delay in epidemic growth during the first 50 days of the coronavirus disease 2019 (COVID-19) epidemic in China, according to a study published online March 31 in Science.

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Burden of Clostridioides difficile Infection Down in the U.S.

THURSDAY, April 2, 2020 (HealthDay News) — From 2011 to 2017, there was a decrease in the estimated national burden of Clostridium difficile infection, according to a study published in the April 2 issue of the New England Journal of Medicine.

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Imported Masks, Other Medical Supplies Arriving in U.S.

WEDNESDAY, April 1, 2020 (HealthDay News) — For the first time since February, imported N95 medical masks are arriving in the United States, but they are not nearly enough to meet demand as COVID-19 cases climb.

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Half of People With COVID-19 Do Not Have Symptoms, Iceland Testing Shows

WEDNESDAY, April 1, 2020 (HealthDay News) — Up to half of people who test positive for the new coronavirus do not have symptoms, results from Iceland show.

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Persistent Positive SARS-CoV-2 Found in Sputum, Feces Samples

WEDNESDAY, April 1, 2020 (HealthDay News) — Some patients with coronavirus disease 2019 (COVID-19) remain positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in sputum or feces after pharyngeal samples become negative, according to a research letter published online March 30 in the Annals of Internal Medicine.

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Ocular Abnormalities Seen in One-Third of COVID-19 Patients

WEDNESDAY, April 1, 2020 (HealthDay News) — About one-third of patients with coronavirus disease 2019 (COVID-19) have ocular abnormalities, according to a brief report published online March 31 in JAMA Ophthalmology.

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Editorial

U.S. Coronavirus Death Toll Could Reach 240,000, Task Force Warns

WEDNESDAY, April 1, 2020 (HealthDay News) — The White House coronavirus task force delivered a tough statistic to Americans late Tuesday, warning that the U.S. death toll from COVID-19 could climb to 240,000, even with social distancing policies in place.

CBS News Article
Johns Hopkins University
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