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Aptamers for CD Antigens: From Cell Profiling to Activity Modulation.

Aptamers for CD Antigens: From Cell Profiling to Activity Modulation.
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Nozari A, Berezovski MV,


Nozari A, Berezovski MV, (click to view)

Nozari A, Berezovski MV,

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Molecular therapy. Nucleic acids 2016 12 106() 29-44 pii 10.1016/j.omtn.2016.12.002

Abstract

Nucleic acid-based aptamers are considered to be a promising alternative to antibodies because of their strong and specific binding to diverse targets, fast and inexpensive chemical synthesis, and easy labeling with a fluorescent dye or therapeutic agent. Cluster of differentiation (CD) proteins are among the most popular antigens for aptamers on the cell surface. These anti-CD aptamers could be used in cell biology and biomedicine, from simple cell phenotyping by flow cytometry or fluorescent microscopy to diagnosis and treatment of HIV/AIDS to cancer and immune therapies. The unique feature of aptamers is that they can act simultaneously as an agonist and antagonist of CD receptors depending on a degree of aptamer oligomerization. Aptamers can also deliver small interfering RNA to silence vital genes in CD-positive cells. In this review, we summarize nucleic acid sequences of anti-CD aptamers and their use, which have been validated in multiple studies.

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