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Aqueous humor polymerase chain reaction in uveitis – utility and safety.

Aqueous humor polymerase chain reaction in uveitis – utility and safety.
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Chronopoulos A, Roquelaure D, Souteyrand G, Seebach JD, Schutz JS, Thumann G,


Chronopoulos A, Roquelaure D, Souteyrand G, Seebach JD, Schutz JS, Thumann G, (click to view)

Chronopoulos A, Roquelaure D, Souteyrand G, Seebach JD, Schutz JS, Thumann G,

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BMC ophthalmology 2016 Oct 2816(1) 189
Abstract
BACKGROUND
To study the value and safety of aqueous humor polymerase chain reaction (PCR) analysis for Herpes simplex, varicella zoster, cytomegalovirus, Epstein-Barr virus and Toxoplasma gondii in patients with uveitis.

METHODS
Records of 45 consecutive patients with anterior and posterior uveitis who underwent AC paracentesis with PCR were reviewed. The main outcome measure was frequency of PCR positivity. Secondary outcomes were alteration of treatment, safety of paracentesis, and correlation of keratitic precipitates with PCR positivity, RESULTS: The overall PCR positivity was 48.9 % (22/45). Therapy was changed because of the PCR results in 14/45 patients (37.7 %). One patient experienced a paracentesis related complication (1/45, 2.2 %) without long-term sequelae.

CONCLUSION
Aqueous PCR altered the diagnosis and treatment in over a third of our patients and was relatively safe. Aqueous PCR should be considered for uveitis of atypical clinical appearance, recurrent severe uveitis of uncertain etiology, and therapy refractory cases.

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