Aging is related to an expanded predominance of subclinical atherosclerosis and stiffening of the arterial walls (arteriosclerosis). These 2 coexisting together conditions are alleviated by the presence of ideal cardiovascular wellbeing (ideal degrees of fasting blood glucose, cholesterol, resting blood pressure, body mass index, no smoking, good dietary quality, and normal active work). We hypothesized that the accompanying presence of subclinical atherosclerosis (coronary artery calcification), arteriosclerosis (higher carotid-femoral pulse wave velocity), and suboptimal cardiovascular wellbeing is related to an expanded danger of cardiovascular disease in comparison with the shortfall of these 3 conditions. We tried our hypothesis locally based Framingham Heart Study cohort (N=2580, average age (in years) = 52, % of female= 49). We grouped members dependent on (1) the presence against absenteeism of coronary artery calcium; (2) higher (> gender-specific median) carotid-femoral pulse wave velocity; (3) poor cardiovascular wellbeing (score 0 to 7). Hence, there should be no irregularities (referent gathering), 1, 2, or 3 suboptimal measures in the members. We utilized Cox regression to relate the number of suboptimal measures (0 to 3) to the incidence of cardiovascular sickness during follow-up (median years = 14). Cardiovascular illness rate rates/1000 person-years in groups with 0-3 suboptimal measures were 1.93 (95% CI, 1.28–2.90), 4.68 (95% CI, 3.48–6.29), 8.93 (95% CI, 6.99–11.41), and 18.26 (95% CI, 14.65–22.77), correspondingly. Relating multivariable-variable risks proportions for cardiovascular disease were 1.81, 2.18, and 3.71, respectively (P is less than 0.05 for all) in comparison to the group without any abnormalities. Though their absence indicates low risk, our perceptions propose that the conjoint presence of atherosclerosis, arteriosclerosis and poor cardiovascular wellbeing generously lifts cardiovascular infection hazard.