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Association between B-type natriuretic peptide and within-visit blood pressure variability.

Association between B-type natriuretic peptide and within-visit blood pressure variability.
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Rodrigues AB, Gismondi RA, Lagoeiro A, Cecilio AM, Marques D, Arita R, Folegatti T, Rosa ML,


Rodrigues AB, Gismondi RA, Lagoeiro A, Cecilio AM, Marques D, Arita R, Folegatti T, Rosa ML, (click to view)

Rodrigues AB, Gismondi RA, Lagoeiro A, Cecilio AM, Marques D, Arita R, Folegatti T, Rosa ML,

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Clinical cardiology 2018 03 31() doi 10.1002/clc.22953
Abstract
BACKGROUND
Blood pressure variability (BPV) has been shown to predict cardiovascular events. Within-visit BPV is the simplest and easiest measure of BPV, but previous studies have shown conflicts as to whether within-visit BPV correlates with target organ damage. We aimed to evaluate whether within-visit BPV correlates with BNP in a general population.

HYPOTHESIS
Within-visit BPV correlates with BNP in a general population.

METHODS
This was a cross sectional study that included 633 individuals, randomly selected, aged 45-99 years, registered in the primary care program from an urban medium-sized town. Patients were scheduled for a single-day visit that consisted of clinical evaluation and laboratory tests. Three BP readings, one minute apart, were done and within-visit BPV was determined as the coefficient of variation (CV) of the three BP measures. Our main outcome was to correlate BNP and within-visit BPV. Multivariable model was estimated using a generalized linear model to evaluate the independent effect of different variables on BNP levels.

RESULTS
Median age was 57 years. Median BNP was 16 pg/ml and the median systolic and diastolic BP-CV were, respectively, 3.9 and 3.5%. There was a weak but positive correlation between BNP and both systolic and diastolic BP-CV (r=0.107 and p=0.007 and r=0.092 and p=0.019, respectively). In multiple regression equation, systolic BP, diastolic BP-CV, BMI and eGFR were associated with BNP.

CONCLUSIONS
In the present study, there was a positive albeit weak correlation between within-visit BPV and BNP. In addition, diastolic BPV was associated with BNP even after adjustment for multiple confounders.

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