Clinical cardiology 2018 03 31() doi 10.1002/clc.22953
Blood pressure variability (BPV) has been shown to predict cardiovascular events. Within-visit BPV is the simplest and easiest measure of BPV, but previous studies have shown conflicts as to whether within-visit BPV correlates with target organ damage. We aimed to evaluate whether within-visit BPV correlates with BNP in a general population.
Within-visit BPV correlates with BNP in a general population.
This was a cross sectional study that included 633 individuals, randomly selected, aged 45-99 years, registered in the primary care program from an urban medium-sized town. Patients were scheduled for a single-day visit that consisted of clinical evaluation and laboratory tests. Three BP readings, one minute apart, were done and within-visit BPV was determined as the coefficient of variation (CV) of the three BP measures. Our main outcome was to correlate BNP and within-visit BPV. Multivariable model was estimated using a generalized linear model to evaluate the independent effect of different variables on BNP levels.
Median age was 57 years. Median BNP was 16 pg/ml and the median systolic and diastolic BP-CV were, respectively, 3.9 and 3.5%. There was a weak but positive correlation between BNP and both systolic and diastolic BP-CV (r=0.107 and p=0.007 and r=0.092 and p=0.019, respectively). In multiple regression equation, systolic BP, diastolic BP-CV, BMI and eGFR were associated with BNP.
In the present study, there was a positive albeit weak correlation between within-visit BPV and BNP. In addition, diastolic BPV was associated with BNP even after adjustment for multiple confounders.